{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:24:02Z","timestamp":1790828642659,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To estimate the time trends in the annual incidence of patients hospitalized for acute coronary syndrome (ACS) in France from 2009 to 2021 and to analyse the current sex and social differences in ACS, management, and prognosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>All patients hospitalized for ACS in France were selected from the comprehensive National Health Insurance database. Age-standardized rates were computed overall and according to age group (over or under 65 years), sex, proxy of socioeconomic status, and ACS subtype [ST-segment elevation (STSE) and non-ST-segment elevation]. Patient characteristics and outcomes were described for patients hospitalized in 2019. Differences in management (coronarography, revascularization), and prognosis were analysed by sex, adjusting for cofonders. In 2019, 143,670 patients were hospitalized for ACS, including 53,227 STSE-ACS (mean age = 68.8 years; 32% women). Higher standardized incidence rates among the most socially deprived people were observed. Women were less likely to receive coronarography and revascularization but had a higher excess in-hospital mortality. In 2019, the age-standardized rate for hospitalized ACS patients reached 210 per 100 000 person-year. Between 2009 and 2019, these rates decreased by 11.4% (men: \u221211.2%; women: \u221214.0%). Differences in trends of age-standardized incidence rate have been observed according to sex, age, and social status. Middle aged women (45\u201364 years) showing more unfavourable trends than in other age classes or in men. In addition, among women the temporal trends were more unfavourable as social deprivation increased.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite encouraging overall trends in patients hospitalized for ACS rates, the increasing trends observed among middle-aged women, especially socially deprived women, is worrying. Targeted cardiovascular prevention and close surveillance of this population should be encouraged.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad288","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:42:45Z","timestamp":1696488165000},"page":"116-127","source":"Crossref","is-referenced-by-count":21,"title":["Nationwide time trends in patients hospitalized for acute coronary syndrome: a worrying generational and social effect among women"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-1510","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Grave","sequence":"first","affiliation":[{"name":"Surveillance des maladies cardio-neuro-vasculaires, Direction des maladies non transmissibles, Sant\u00e9 publique France , 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-8988","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Gabet","sequence":"additional","affiliation":[{"name":"Surveillance des maladies cardio-neuro-vasculaires, Direction des maladies non transmissibles, Sant\u00e9 publique France , 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Cinaud","sequence":"additional","affiliation":[{"name":"Centre de diagnostic et de th\u00e9rapeutique, H\u00f4pital H\u00f4tel-Dieu AP-HP, Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Tuppin","sequence":"additional","affiliation":[{"name":"Direction de la strat\u00e9gie, des \u00e9tudes et des statistiques, Caisse Nationale de l'Assurance Maladie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-4279","authenticated-orcid":false,"given":"Jacques","family":"Blacher","sequence":"additional","affiliation":[{"name":"Centre de diagnostic et de th\u00e9rapeutique, H\u00f4pital H\u00f4tel-Dieu AP-HP, Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-1930","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Oli\u00e9","sequence":"additional","affiliation":[{"name":"Surveillance des maladies cardio-neuro-vasculaires, Direction des maladies non transmissibles, Sant\u00e9 publique France , 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"2024032723204696600_zwad288-B1","doi-asserted-by":"crossref","first-page":"559751","DOI":"10.3389\/fpubh.2021.559751","article-title":"Global, regional, and national death, and disability-adjusted life-years (DALYs) for cardiovascular disease in 2017 and trends and risk analysis from 1990 to 2017 using the global burden of disease study and implications for prevention","volume":"9","author":"Li","year":"2021","journal-title":"Front Public Health"},{"key":"2024032723204696600_zwad288-B2","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1136\/heartjnl-2014-307310","article-title":"Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations","volume":"101","author":"D\u00e9gano","year":"2015","journal-title":"Heart"},{"key":"2024032723204696600_zwad288-B3","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1080\/07853890.2021.2002926","article-title":"Epidemiological trends in mortality, event rates and case fatality of acute myocardial infarction from 2004 to 2015: results from the KORA MI registry","volume":"53","author":"Kr\u00e4mer","year":"2021","journal-title":"Ann Med"},{"key":"2024032723204696600_zwad288-B4","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1177\/2047487318780033","article-title":"Trends in incident acute myocardial infarction in Norway: an updated analysis to 2014 using national data from the CVDNOR project","volume":"25","author":"Sulo","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"2024032723204696600_zwad288-B5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/ehjqcco\/qcv016","article-title":"Incidence and outcome of first myocardial infarction according to gender and age in Denmark over a 35-year period (1978\u20132012)","volume":"1","author":"Alzuhairi","year":"2015","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"2024032723204696600_zwad288-B6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/jwh.2013.4507","article-title":"Do younger women fare worse? 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