{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:18:21Z","timestamp":1790083101620,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970239"],"award-info":[{"award-number":["81970239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070315"],"award-info":[{"award-number":["82070315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200900"],"award-info":[{"award-number":["82200900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"GuangDong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2023A1515010381"],"award-info":[{"award-number":["2023A1515010381"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"GuangDong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2022A1515220013"],"award-info":[{"award-number":["2022A1515220013"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M721495"],"award-info":[{"award-number":["2022M721495"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of General Hospital of Southern Theater Command","award":["2021NZC028"],"award-info":[{"award-number":["2021NZC028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Remnant cholesterol (RC) reportedly mediates residual cardiovascular risk in atherosclerotic cardiovascular diseases (ASCVD). However, few studies have characterized long-term cumulative RC exposure among elderly people. The study aimed to evaluate the association between cumulative exposure to RC and incident major adverse cardiovascular events (MACE) by analysing a cohort of elderly patients with ASCVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This retrospective multicentre cohort study enrolled ASCVD participants aged \u226575 years with baseline visits occurring from 2006 to 2012 followed by four in-person visits. Cumulative RC was estimated as the area under the curve using measurements from the first to fourth visits by using 9-year data. The time-weighted average (TWA) RC was expressed as cumulative exposure to RC averaged by years. All outcomes were follow-up from the fourth visit to the year 2021. Outcomes included a composite of MACE (stroke, unstable angina pectoris, myocardial infarction, and cardiac death). We included 4,680 participants (73.1% male, mean age 79.3 \u00b1 2.5 years). The median follow-up duration was 6.1 years (interquartile range: 3.4\u20136.6 years). In the multivariable model adjusted for traditional cardiovascular risk factors, low-density lipoprotein cholesterol level, and most recent RC level, the hazard ratios for MACE that compared the high and low tertiles of the RC variables were 1.30 [95% confidence interval (CI), 1.16\u20131.44] for cumulative RC and 1.36 (95% CI, 1.23\u20131.52) for TWA RC. Consistent significant associations were observed among most propensity score analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Long-term cumulative RC was independently associated with incident MACE in elderly participants with ASCVD, suggesting that achieving and maintaining optimal RC levels later in life may still improve cardiovascular outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad297","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:18:53Z","timestamp":1694729933000},"page":"1924-1934","source":"Crossref","is-referenced-by-count":29,"title":["Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease"],"prefix":"10.1093","volume":"30","author":[{"given":"Zhiwen","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Department of Geriatrics, General Hospital of Southern Theater Command, People's Liberation Army , 111 Liuhua Road, Guangzhou 510010 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, General Hospital of Southern Theater Command, People's Liberation Army , 111 Liuhua Road, Guangzhou 510010 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuegang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiquan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, General Hospital of Southern Theater Command, People's Liberation Army , 111 Liuhua Road, Guangzhou 510010 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-390X","authenticated-orcid":false,"given":"Yulin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Bin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0576-483X","authenticated-orcid":false,"given":"Yanmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou 510515 , China"},{"name":"Department of Cardiology, Ganzhou People's Hospital , 16 Meiguan Avenue, Ganzhou 341000, 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