{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:31:26Z","timestamp":1793107886449,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["20-B-0206"],"award-info":[{"award-number":["20-B-0206"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009618","name":"Sundhed, Region Midt","doi-asserted-by":"publisher","award":["A3116"],"award-info":[{"award-number":["A3116"]}],"id":[{"id":"10.13039\/501100009618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL092577"],"award-info":[{"award-number":["R01HL092577"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA_18SFRN34110082"],"award-info":[{"award-number":["AHA_18SFRN34110082"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0031258"],"award-info":[{"award-number":["NNF18OC0031258"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065151"],"award-info":[{"award-number":["NNF20OC0065151"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Obesity is a major risk factor for atrial fibrillation (AF). Compared with stable weight, gaining weight was associated with a higher risk of incident AF in observational studies. The results, however, are conflicting regarding weight loss and risk of AF. This study aimed to assess the association between 5-year weight changes and risk of incident AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study was based on participants from the Danish Diet, Cancer, and Health Cohort. Body mass index (BMI) was assessed at a baseline examination and at a second examination 5 years later. Diagnoses of AF and co-morbidities were retrieved from the Danish National Patient Registry. In total, 43 758 participants without prior AF were included. The median age was 61 years and 54% were female. During a median follow-up of 15.7 years, 5312 individuals had incident AF (incidence rate 8.6\/1000 person-years). Compared with stable weight, weight gain between 2.5 and 5 BMI units (kg\/m2) was associated with a higher risk of AF [hazard ratio (HR) 1.24, 95% confidence interval (CI) 1.09\u20131.41]. Weight gain of 5 or more BMI units (kg\/m2) was associated with a HR of 1.95 (95% CI 1.48\u20132.56) of incident AF. However, there was no statistically significant association between weight loss and risk of AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Five-year weight gain was associated with greater risk of AF compared with stable weight in the Danish Diet, Cancer, and Health Cohort. There was no statistically significant association between weight loss and risk of AF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad300","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:15:36Z","timestamp":1694729736000},"page":"244-249","source":"Crossref","is-referenced-by-count":9,"title":["Five-year changes in weight and risk of atrial fibrillation in the Danish Diet, Cancer, and Health Cohort"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-9297","authenticated-orcid":false,"given":"Tanja Charlotte","family":"Frederiksen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N , Denmark"},{"name":"Department of Clinical Medicine, Health, Aarhus University , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-888X","authenticated-orcid":false,"given":"Morten Krogh","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4076-2336","authenticated-orcid":false,"given":"Emelia J","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine , Boston, MA , USA"},{"name":"Department of Epidemiology, Boston University School of Public Health , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-7921","authenticated-orcid":false,"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health, Aarhus University , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-503X","authenticated-orcid":false,"given":"Anja","family":"Olsen","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health, Aarhus University , Aarhus , Denmark"},{"name":"Danish Cancer Society Research Center , K\u00f8benhavn \u00d8 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-2893","authenticated-orcid":false,"given":"Christina Catherine","family":"Dahm","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology, Department of Public Health, Aarhus University , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-4302","authenticated-orcid":false,"given":"Henrik Kj\u00e6rulf","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N , Denmark"},{"name":"Department of Clinical Medicine, Health, Aarhus University , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"2024012511042033200_zwad300-B1","author":"World Health Organization"},{"key":"2024012511042033200_zwad300-B2","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1093\/eurheartj\/ehab454","article-title":"Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian 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