{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:08:07Z","timestamp":1789448887765,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>It is unclear how serial high-sensitivity troponin-I (hsTnI) concentrations affect long-term prognosis in individuals with suspected acute coronary syndrome (ACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Subjects who underwent two hsTnI measurements (Siemens TnI Flex\u00ae Reagent) separated by 1\u20137\u2005h, during a first-time hospitalization for myocardial infarction, unstable angina, observation for suspected myocardial infarction, or chest pain from 2012 through 2019, were identified through Danish national registries. Individuals were stratified per their hsTnI concentration pattern (normal, rising, persistently elevated, or falling) and the magnitude of hsTnI concentration change (&amp;lt;20%, &amp;gt;20\u201350%, or &amp;gt;50% in either direction). We calculated absolute and relative mortality risks standardized to the distributions of risk factors for the entire study population. A total of 20 609 individuals were included of whom 2.3% had died at 30 days, and an additional 4.7% had died at 365 days. The standardized risk of death was highest among persons with a persistently elevated hsTnI concentration (0\u201330 days: 8.0%, 31\u2013365 days: 11.1%) and lowest among those with two normal hsTnI concentrations (0\u201330 days: 0.5%, 31\u2013365 days: 2.6%). In neither case did relative hsTnI concentration changes between measurements clearly affect mortality risk. Among persons with a rising hsTnI concentration pattern, 30-day mortality was higher in subjects with a &amp;gt;50% rise compared with those with a less pronounced rise (2.2% vs. &amp;lt;0.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among individuals with suspected ACS, those with a persistently elevated hsTnI concentration consistently had the highest risk of death. In subjects with two normal hsTnI concentrations, mortality was very low and not affected by the magnitude of change between measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad373","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T01:13:31Z","timestamp":1701911611000},"page":"615-626","source":"Crossref","is-referenced-by-count":6,"title":["Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-5825","authenticated-orcid":false,"given":"Manan","family":"Pareek","sequence":"first","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"},{"name":"Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Meta Dyrvig","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-1953","authenticated-orcid":false,"given":"Muthiah","family":"Vaduganathan","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats Christian","family":"H\u00f8jbjerg Lassen","sequence":"additional","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-3236","authenticated-orcid":false,"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-7511","authenticated-orcid":false,"given":"Kristoffer Grundtvig","family":"Skaarup","sequence":"additional","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Rosberg","sequence":"additional","affiliation":[{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik L","family":"Pallisgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B\u00f8dtker","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer B","family":"Polcwiartek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Frangeskos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peconic Bay Medical Center at Northwell Health , Riverhead, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cian P","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6794-8726","authenticated-orcid":false,"given":"Anders Nissen","family":"Bonde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Ji-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil L","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Thue","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar H","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Hellerup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014North Zealand Hospital , Hiller\u00f8d , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":false,"given":"Deepak L","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai , NewYork, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian H","family":"Kragholm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Aalborg , 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