{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:56Z","timestamp":1792794116421,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"CircM network, Link\u00f6ping University","id":[{"id":"https:\/\/ror.org\/05ynxx418","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Research Foundation Flanders, Belgium","award":["1225021N"],"award-info":[{"award-number":["1225021N"]}],"id":[{"id":"https:\/\/ror.org\/03qtxy027","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Research Council KU Leuven","award":["C24M\/21\/025"],"award-info":[{"award-number":["C24M\/21\/025"]}],"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate the association between the exercise systolic blood pressure (SBP) response and future hypertension (HTN) in normotensive individuals referred for cycle ergometry, with special regard to reference exercise SBP values and exercise capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this longitudinal cohort study, data from 14 428 exercise tests were cross-linked with Swedish national registries on diagnoses and medications. We excluded individuals with a baseline diagnosis of cardiovascular disease or HTN. The peak exercise SBP (SBPpeak) was recorded and compared with the upper limit of normal (ULN) derived from SBPpeak reference equations incorporating age, sex, resting SBP, and exercise capacity. To evaluate the impact of exercise capacity, three SBP to work rate slopes (SBP\/W-slopes) were calculated, relative to either supine or seated SBP at rest or to the first exercise SBP. Adjusted hazard ratios [HRadjusted (95% confidence interval, CI)] for incident HTN during follow-up, in relation to SBP response metrics, were calculated. We included 3895 normotensive individuals (49 \u00b1 14 years, 45% females) with maximal cycle ergometer tests. During follow-up (median 7.5 years), 22% developed HTN. Higher SBPpeak and SBPpeak &amp;gt; ULN were associated with incident HTN [HRadjusted 1.19 (1.14\u20131.23) per 10\u2005mmHg, and 1.95 (1.54\u20132.47), respectively]. All three SBP\/W-slopes were positively associated with incident HTN, particularly the SBP\/W-slope calculated as supine-to-peak SBP [HRadjusted 1.25 (1.19\u20131.31) per 1\u2005mmHg\/10\u2005W].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both SBPpeak &amp;gt; ULN based on reference values and high SBP\/W-slopes were associated with incident HTN in normotensive individuals and should be considered in the evaluation of the cycle ergometry SBP response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae012","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T09:31:59Z","timestamp":1704792719000},"page":"1072-1079","source":"Crossref","is-referenced-by-count":25,"title":["Exercise systolic blood pressure response during cycle ergometry is associated with future hypertension in normotensive individuals"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-7820","authenticated-orcid":false,"given":"Anna","family":"Carl\u00e9n","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology in Link\u00f6ping, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , Link\u00f6ping S-581 83 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-0034","authenticated-orcid":false,"given":"Thomas","family":"Lindow","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Research and Development, V\u00e4xj\u00f6 Central Hospital, Region Kronoberg , V\u00e4xj\u00f6 , Sweden"},{"name":"Clinical Physiology, Clinical Scienes, Lund University , Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-7692","authenticated-orcid":false,"given":"Nicholas","family":"Cauwenberghs","sequence":"additional","affiliation":[{"name":"Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-9306","authenticated-orcid":false,"given":"Viktor","family":"Elmberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Blekinge Hospital , Karlskrona , Sweden"},{"name":"Department of Clinical Sciences, Division of Respiratory Medicine, Allergology, and Palliative Medicine, Lund University , Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-1362","authenticated-orcid":false,"given":"Lars","family":"Brudin","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Kalmar County Hospital , Kalmar , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-5113","authenticated-orcid":false,"given":"Magnus","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Respiratory Medicine, Allergology, and Palliative Medicine, Lund University , Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-7180","authenticated-orcid":false,"given":"Kristofer","family":"Hedman","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology in Link\u00f6ping, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , Link\u00f6ping S-581 83 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"2024072313511088100_zwae012-B1","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/eurheartj\/ehr080","article-title":"Achievement of treatment goals for primary prevention of cardiovascular disease in clinical practice across Europe: the EURIKA study","volume":"32","author":"Banegas","year":"2011","journal-title":"Eur Heart J"},{"key":"2024072313511088100_zwae012-B2","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"2024072313511088100_zwae012-B3","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIR.0b013e31829b5b44","article-title":"Exercise standards 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