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Methionine is obtained from dietary proteins, such as poultry, meat, eggs, seafood, and dairy products. Abnormalities in Hcy metabolic pathways, deficiencies in dietary methionine, folate, and vitamins B12, B6, and B2 and genetic defects, polymorphisms, or mutations in Hcy metabolism-related enzymes may lead to an increase in plasma Hcy levels. Generally, a plasma Hcy level higher than 10 or 15\u2005\u03bcmol\/L has been defined as hyperhomocysteinemia (HHcy). An individual with essential hypertension complicated with HHcy is considered to have H-type hypertension (HTH). Currently, HHcy is considered a novel independent risk factor for various cardiovascular diseases. To provide a useful reference for clinicians, the research progress on Hcy, HHcy, and HTH in recent years was systematically reviewed here, with a focus on the source and metabolic pathways of Hcy, plasma Hcy levels and influencing factors, detection methods for plasma Hcy levels, relationship between Hcy concentration and hypertension, pathogenesis of HTH, cardiovascular complications of HTH, and treatment of HTH.<\/jats:p>","DOI":"10.1093\/eurjpc\/zwae022","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:43:20Z","timestamp":1705589000000},"page":"1092-1103","source":"Crossref","is-referenced-by-count":97,"title":["Homocysteine, hyperhomocysteinemia, and H-type hypertension"],"prefix":"10.1093","volume":"31","author":[{"given":"Dong-Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Geriatric Cardiology, Guangxi Academy of Medical Sciences and the People\u2019s Hospital of Guangxi Zhuang Autonomous Region , 6 Taoyuan Road, Nanning 530021, Guangxi , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-4310","authenticated-orcid":false,"given":"Rui-Xing","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University , 6 Shuangyong Road, Nanning 530021, Guangxi , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Long","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Cardiology, Guangxi Academy of Medical Sciences and the People\u2019s Hospital of Guangxi Zhuang Autonomous Region , 6 Taoyuan Road, Nanning 530021, Guangxi , People\u2019s Republic of 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