{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:12:49Z","timestamp":1787807569673,"version":"build-2784847793"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2018YFC1312803"],"award-info":[{"award-number":["2018YFC1312803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974266"],"award-info":[{"award-number":["81974266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Key Research and Development Program","award":["202206080014"],"award-info":[{"award-number":["202206080014"]}]},{"DOI":"10.13039\/501100010112","name":"President\u2019s Fund of Nanfang Hospital","doi-asserted-by":"publisher","award":["2019Z002"],"award-info":[{"award-number":["2019Z002"]}],"id":[{"id":"10.13039\/501100010112","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects in Guangzhou","award":["SL2022A04J02040"],"award-info":[{"award-number":["SL2022A04J02040"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["202201010631"],"award-info":[{"award-number":["202201010631"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The lack of effective pharmacotherapies for aortic aneurysms (AA) is a persistent clinical challenge. Lipid metabolism plays an essential role in AA. However, the impact of lipid-lowering drugs on AA remains controversial. The study aimed to investigate the genetic association between lipid-lowering drugs and AA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Our research used publicly available data on genome-wide association studies (GWASs) and expression quantitative trait loci (eQTL) studies. Genetic instruments, specifically eQTLs related to drug-target genes and SNPs (single nucleotide polymorphisms) located near or within the drug-target loci associated with low-density lipoprotein cholesterol (LDL-C), have been served as proxies for lipid-lowering medications. Drug-Target Mendelian Randomization (MR) study is used to determine the causal association between lipid-lowering drugs and different types of AA. The MR analysis revealed that higher expression of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) was associated with increased risk of AA (OR = 1.58, 95% CI = 1.20\u20132.09, P = 1.20 \u00d7 10\u221203) and larger lumen size (aortic maximum area: OR = 1.28, 95% CI = 1.13\u20131.46, P = 1.48 \u00d7 10\u221204; aortic minimum area: OR = 1.26, 95% CI = 1.21\u20131.42, P = 1.78 \u00d7 10\u221204). PCSK9 (proprotein convertase subtilisin\/kexin type 9) and CETP (cholesteryl ester transfer protein) show a suggestive relationship with AA (PCSK9: OR = 1.34, 95% CI = 1.10\u20131.63, P = 3.07 \u00d7 10\u221203; CETP: OR = 1.38, 95% CI = 1.06\u20131.80, P = 1.47 \u00d7 10\u221202). No evidence to support genetically mediated NPC1L1 (Niemann\u2013Pick C1-Like 1) and LDLR (low-density lipoprotein cholesterol receptor) are associated with AA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study provides causal evidence for the genetic association between lipid-lowering drugs and AA. Higher gene expression of HMGCR, PCSK9, and CETP increases AA risk. Furthermore, HMGCR inhibitors may link with smaller aortic lumen size.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae044","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:03:11Z","timestamp":1706835791000},"page":"1132-1140","source":"Crossref","is-referenced-by-count":11,"title":["Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-7206","authenticated-orcid":false,"given":"Xiong","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Boluo County People\u2019s Hospital , No. 1 Kangbo West Road, Luoyang Street, Boluo County, Huizhou City, Guangdong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) , 1017 Dongmen North Road, Luohu District, Shenzhen City, Guangdong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-390X","authenticated-orcid":false,"given":"Yulin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Pui-Wai","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital and Laboratory of Cardiac Imaging and 3D Printing, Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong Special Administrative Region , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nanfang Hospital, Southern Medical University , 1838 Guangzhou Avenue North, Baiyun District, Guangzhou City, Guangdong Province 510515 , 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