{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:03:36Z","timestamp":1790870616177,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2021-06432"],"award-info":[{"award-number":["2021-06432"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2021-03690"],"award-info":[{"award-number":["2021-03690"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["20210184"],"award-info":[{"award-number":["20210184"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MedTech4Health","award":["2016-02211"],"award-info":[{"award-number":["2016-02211"]}]},{"name":"The Swedish CArdioPulmonary bioImage Study"},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Gothenburg and Sahlgrenska University Hospital"},{"name":"Karolinska Institutet and Stockholm County Council"},{"name":"Link\u00f6ping University and University Hospital"},{"name":"Lund University and Sk\u00e5ne University Hospital"},{"name":"Ume\u00e5 University and University Hospital"},{"name":"Uppsala University and University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim was to investigate the relationship between microvascular function, cardiovascular risk profile, and subclinical atherosclerotic burden.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study enrolled 3809 individuals, 50\u201365 years old, participating in the population-based observational cross-sectional Swedish CArdioPulmonary bioImage Study. Microvascular function was assessed in forearm skin using an arterial occlusion and release protocol determining peak blood oxygen saturation (OxyP). Cardiovascular risk was calculated using the updated Systematic Coronary Risk Evaluation [SCORE2; 10-year risk of fatal and non-fatal cardiovascular disease (CVD) events]. The OxyP was compared with coronary artery calcification score (CACS) and to plaques in the carotid arteries. Individuals with OxyP values in the lowest quartile (Q1; impaired microvascular function) had a mean SCORE2 of 5.8% compared with 3.8% in those with the highest values of OxyP (Q4), a relative risk increase of 53%. The risk of having a SCORE2 &amp;gt; 10% was five times higher for those in Q1 (odds ratio: 4.96, 95% confidence interval: 2.76\u20138.93) vs. Q4 when adjusting for body mass index and high-sensitivity C-reactive protein. The OxyP was lower in individuals with CACS &amp;gt; 0 and in those with both carotid plaques and CACS &amp;gt; 0, compared with individuals without subclinical atherosclerotic burdens (87.5 \u00b1 5.6% and 86.9 \u00b1 6.0%, vs. 88.6 \u00b1 5.8%, P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In a population without CVD or diabetes mellitus, impaired microvascular function is associated with cardiovascular risk profiles such as higher SCORE2 risk and CACS. We suggest that OxyP may serve as a microcirculatory functional marker of subclinical atherosclerosis and CVD risk that is not detected by structural assessments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae052","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T09:30:04Z","timestamp":1707471004000},"page":"1152-1161","source":"Crossref","is-referenced-by-count":14,"title":["Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study)"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9663-3720","authenticated-orcid":false,"given":"Sara","family":"Bergstrand","sequence":"first","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , Building 511, Entrance 75, Room 13.1309 Campus US, 581 83 Link\u00f6ping , 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