{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:27:16Z","timestamp":1788550036838,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Over time, cardiovascular disease (CVD) deaths increasingly exceed those from malignancy among cancer survivors. However, the association of myocardial injury with long-term survival (beyond 3 years) in cancer patients has not been previously described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The high-sensitivity cardiac troponin (hs-cTn) and morbidities databases from the National Health and Nutrition Examination Survey (1999\u20132004) were linked with the latest mortality dataset isolating records were respondents reported cancer diagnosis by a healthcare professional. Myocardial injury was then determined by elevated hs-cTn. A total of 16 225 560 weighted records (1058 unweighted) were included in this observational study, with myocardial injury identified in 14.2%. Those with myocardial injury had progressively worse survival at 5 (51.6 vs. 89.5%), 10 (28.3 vs. 76.0%), and 15 years (12.6 vs. 61.4%) compared with those without myocardial injury. After adjusting for baseline characteristics, those with myocardial injury had an adjusted hazard ratio (aHR) of 2.10 [95% confidence interval (CI) 2.09\u20132.10, P &amp;lt; 0.001] for all-cause mortality, 2.23 (2.22\u20132.24, P &amp;lt; 0.001) for cardiovascular mortality, and 1.59 (95% CI 1.59\u20131.60, P &amp;lt; 0.001) for cancer mortality compared with those without myocardial injury. Among patients with no pre-existing CVD, the hs-cTn I Ortho assay was a strong independent predictor of all-cause (aHR 6.29, 95% CI 6.25\u20136.33, P &amp;lt; 0.001), CVD (aHR 11.38, 95% CI 11.23\u201311.54, P &amp;lt; 0.001), and cancer (aHR 5.02, 95% CI 4.96\u20135.07, P &amp;lt; 0.001) mortalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a marker for myocardial injury, hs-cTns were independently associated with worse long-term survival among cancer patients with a stronger relationship with all-cause, cardiovascular, and cancer mortalities using hs-cTn I Ortho assay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae116","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T19:04:56Z","timestamp":1710875096000},"page":"548-556","source":"Crossref","is-referenced-by-count":9,"title":["Association of myocardial 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Institute for Primary Care and Health Sciences, Keele University , Keele, Staffordshire, ST5 5BG ,","place":["UK"]},{"name":"Department of Cardiology, Hillel Yaffe Medical Centre , Ha-Shalom Street, Hadera, 3820302 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-7829","authenticated-orcid":false,"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Southampton , University Road, Southampton, SO17 1BJ ,","place":["UK"]},{"name":"The Coronary Research Group, University Hospital Southampton NHS Foundation Trust , Tremona Road, Southampton, SO16 6YD ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":false,"given":"Mamas A","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute 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