{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:51:08Z","timestamp":1792003868898,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While high-volume physical activity (PA) has been linked to elevated coronary artery calcification (CAC), the role of intensity vs. duration of PA has not been investigated. The purpose of the study was to examine the role of intensity vs. duration of PA in relation to CAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Data are from 23 383 apparently healthy men who completed a PA questionnaire and underwent CAC scanning as part of a preventive examination. Self-reported PA was categorized into four groups of average intensity and weekly duration of PA [average intensity: 1, 3\u20135.9, 6\u20138.9, and 9\u201312 metabolic equivalents of task (METs); weekly duration: 0, &amp;gt; 0\u2212&amp;lt;2, 2\u2212&amp;lt;5, and \u22655\u2005h\/week]. Mean CAC and CAC \u2265 100 Agatston units (AU) were regressed separately on continuous or categorical average intensity and weekly duration of PA. The mean (standard deviation) age was 51.7 (8.3) years, and mean CAC was 174.8 (543.6) AU with 23.5% of men presenting with CAC \u2265 100\u2005AU. Higher average intensity of PA was related to lower mean CAC [\u22123.1%\/MET, 95% confidence interval (CI): \u22124.6, \u22121.6%\/MET] and lower relative risk (RR) of CAC \u2265 100\u2005AU (RR: 0.99, 95% CI: 0.98, 1.00\/MET). Opposite trend was observed for the duration component wherein higher weekly duration of PA was significantly associated with greater mean CAC and RR of CAC \u2265 100\u2005AU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated CAC was associated with lower average intensity and longer duration of PA in men, providing new insight into the complex relationship between leisure-time PA behaviours and risk of CAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae150","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T19:22:48Z","timestamp":1713554568000},"page":"1526-1534","source":"Crossref","is-referenced-by-count":23,"title":["Coronary artery calcification and high-volume physical activity: role of lower intensity vs. longer duration of exercise"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-5466","authenticated-orcid":false,"given":"Andjelka","family":"Pavlovic","sequence":"first","affiliation":[{"name":"The Cooper Institute , 12330 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-130X","authenticated-orcid":false,"given":"Laura F","family":"DeFina","sequence":"additional","affiliation":[{"name":"The Cooper Institute , 12330 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Leonard","sequence":"additional","affiliation":[{"name":"The Cooper Institute , 12330 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-9514","authenticated-orcid":false,"given":"Nina B","family":"Radford","sequence":"additional","affiliation":[{"name":"The Cooper Clinic , 12200 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W","family":"Farrell","sequence":"additional","affiliation":[{"name":"The Cooper Institute , 12330 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-7405","authenticated-orcid":false,"given":"Carolyn E","family":"Barlow","sequence":"additional","affiliation":[{"name":"The Cooper Institute , 12330 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-0910","authenticated-orcid":false,"given":"Kerem","family":"Shuval","sequence":"additional","affiliation":[{"name":"The Cooper Institute , 12330 Preston Rd., Dallas, TX 75230 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-8155","authenticated-orcid":false,"given":"Jarett D","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas at Tyler School of Medicine , Tyler, TX 75799 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd., Dallas, TX 75390 , USA"},{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas , TX 75231 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"2024090611512519100_zwae150-B1","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1249\/MSS.0000000000001937","article-title":"Physical activity in cancer prevention and survival: a systematic review","volume":"51","author":"McTiernan","year":"2019","journal-title":"Med Sci Sports Exerc"},{"key":"2024090611512519100_zwae150-B2","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The Physical Activity Guidelines for Americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"key":"2024090611512519100_zwae150-B3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2165\/00007256-200131150-00002","article-title":"Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis","volume":"31","author":"Durstine","year":"2001","journal-title":"Sports Med"},{"key":"2024090611512519100_zwae150-B4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00008483-200211000-00002","article-title":"Lipids, lipoproteins, and exercise","volume":"22","author":"Durstine","year":"2002","journal-title":"J Cardiopulm Rehabil"},{"key":"2024090611512519100_zwae150-B5","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1001\/jama.1989.03430170057028","article-title":"Physical fitness and all-cause mortality. 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