{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:51:36Z","timestamp":1781571096871,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaison Committee for Education, Research and Innovation in Central Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Although parity, infertility, and age at first birth are important for later development of cardiovascular disease, research on their association with atrial fibrillation (AF) is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We linked data from the population-based HUNT study and the Medical Birth Registry of Norway (MBRN) and validated medical records from local hospitals. A total of 24 015 women aged 45 years or older were followed for verified incident AF. Parity and age at first birth were retrieved from the MBRN or from self-reported questionnaires in the HUNT study. A history of infertility was self-reported on the HUNT questionnaire. Cox proportional hazards models were used to calculate hazard ratios (HRs) for the multivariable-adjusted associations of parity, infertility, and age at first birth with risk of AF. During a median follow-up of 12.8 years, 1448 (6.0%) participants developed AF. Women with higher parity (four or more births vs. two births) were at 21% higher risk of AF [HR 1.21, 95% confidence interval (CI) 1.05\u20131.39]. A history of infertility was also associated with the risk of AF (HR 1.20, 95% CI 1.02\u20131.42). Among parous women, younger age at first birth (&amp;lt;20 vs. 20\u201329 years) was associated with a 20% higher risk of AF (HR 1.20, 95% CI 1.03\u20131.40).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Women with four or more births, or a history of infertility, or younger age at first birth have approximately a 20% higher risk of AF among women over 45 years old.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae215","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T07:33:02Z","timestamp":1719819182000},"page":"1645-1652","source":"Crossref","is-referenced-by-count":4,"title":["Parity, infertility, age at first birth, and risk of atrial fibrillation: data from the HUNT study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-4988","authenticated-orcid":false,"given":"Hikaru","family":"Morooka","sequence":"first","affiliation":[{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 8905, N-7491 Trondheim , Norway"},{"name":"Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust , Kirkegata 2, 7600 Levanger , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8565-9151","authenticated-orcid":false,"given":"Eirin B","family":"Haug","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 8905, N-7491 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-7594","authenticated-orcid":false,"given":"Vegard","family":"Malmo","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 7491 Trondheim , Norway"},{"name":"Clinic of Cardiology, St. Olav\u2019s University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-3286","authenticated-orcid":false,"given":"Jan P\u00e5l","family":"Loennechen","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 7491 Trondheim , Norway"},{"name":"Clinic of Cardiology, St. Olav\u2019s University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-6970","authenticated-orcid":false,"given":"Kenneth J","family":"Mukamal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center , 330 Brookline Ave, Boston, MA 02215 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 8905, N-7491 Trondheim , Norway"},{"name":"Center for Oral Health Services and Research (TkMidt) , Professor Brochs gt. 2, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Janszky","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 8905, N-7491 Trondheim , Norway"},{"name":"Regional Center for Health Care Improvement, St. Olav\u2019s University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"},{"name":"Department of Global Public Health, Karolinska Institutet , Norrbackagatan 4, 171 76 Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-9707","authenticated-orcid":false,"given":"Julie","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology , 8905, N-7491 Trondheim , Norway"},{"name":"Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust , Kirkegata 2, 7600 Levanger , 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