{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:43:19Z","timestamp":1787971399426,"version":"build-2784847793"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cold temperatures are known to affect heart failure (HF) hospitalizations, but the dynamic status of multi-morbidity of HF was rarely incorporated. We investigated the relationship between temperature and new-onset HF by risk strata.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This nationwide cohort study analysed daily data on ambient temperature, the dynamic status of risk factors (age, diabetes, chronic obstructive pulmonary disease, coronary artery disease, chronic kidney disease, hypertension, myocardial infarction, and atrial fibrillation), and new-onset HF among the Taiwan population from 2012 to 2019. Poisson regression, Austin\u2019s algorithm, and classification and regression tree (CART) were used to determine risk strata and obtain the predicted HF rate. 148 708 patients developed new-onset HF over 152.52 million person-years. Three risk strata for HF were identified: Stratum 1 was predominantly those without any comorbidity (89.9%); Stratum 2 was those aged 60\u201369 with 2\u20133 comorbidities or aged 70+ with 1\u20132 comorbidities (9.0%), and Stratum 3 was those aged 70+ and had four or more comorbidity (1.1%). The HF incidence rates for these three strata were 25.54, 555.27, and 2315.52 per 100 000 person-years, respectively. The R2 of the Poisson regression with the three risk strata and the daily minimum temperature on the ln HF incidence rates was 77.99%. The risk of HF increased as temperatures decreased, and the slopes were 1.032, 1.040, and 1.034 for Strata 1\u20133, respectively. The rate ratios of HF at the winter median temperature of 17\u00b0C vs. the summer median temperature of 29\u00b0C were 1.45, 1.58, and 1.49 for Strata 1\u20133, respectively. Cross-validation reveals a good fit and predicted HF rates by ambient temperature for the three strata were provided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cold temperatures are associated with an increased risk of new-onset HF. Stratum 2 (aged 60\u201369 with 2\u20133 comorbidities or aged 70+ with 1\u20132 comorbidities) are particularly susceptible to cold-related new-onset HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae260","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T23:32:41Z","timestamp":1724455961000},"page":"2026-2035","source":"Crossref","is-referenced-by-count":7,"title":["The cold temperature associated with new-onset heart failure after incorporating dynamic status of multimorbidity: nationwide cohort, Taiwan 2012\u20132019"],"prefix":"10.1093","volume":"31","author":[{"given":"Dong-Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital at Linkou , Taoyuan City ,","place":["Taiwan"]},{"name":"Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou , Taoyuan City ,","place":["Taiwan"]},{"name":"Department of Medicine, Chang Gung University , Taoyuan City 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Medicine, Chang Gung Memorial Hospital at Linkou , Taoyuan City ,","place":["Taiwan"]},{"name":"Department of Medicine, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-8969","authenticated-orcid":false,"given":"Lai-Chu","family":"See","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou , Taoyuan City ,","place":["Taiwan"]},{"name":"Department of Public Health, College of Medicine, Chang Gung University , Taoyuan City ,","place":["Taiwan"]},{"name":"Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]},{"name":"Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Linkou , Taoyuan City 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