{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:56:56Z","timestamp":1789624616885,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Young Elite Scientists Sponsorship Program"},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["YESS20200151"],"award-info":[{"award-number":["YESS20200151"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Talent Project of Shengjing Hospital of China Medical University","award":["M0294"],"award-info":[{"award-number":["M0294"]}]},{"name":"Scientific Research Project of the Liaoning Province Education Department","award":["LJKMZ20221149"],"award-info":[{"award-number":["LJKMZ20221149"]}]},{"name":"Talent Project of Shengjing Hospital of China Medical University","award":["M1438"],"award-info":[{"award-number":["M1438"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The association between physical activity and venous thromboembolism (VTE) remains unclear. Therefore, we investigated the prospective dose\u2013response associations between accelerometer-measured intensity-specific physical activity and new-onset VTE, accounting for genetic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In total, 85 116 participants from the UK Biobank were included. Incident VTE was identified via linked hospital records and death registries. A weighted polygenic risk score (PRS) was used to quantify genetic risk for VTE, with higher values indicating a high genetic risk. Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of the associations. Overall, 1182 incident VTE cases were documented during a median follow-up of 6.18\u2005years. In the overall study population, the participants in the highest level of the total volume of physical activity [0.60 (0.45, 0.79)], moderate-to-vigorous-intensity physical activity [0.66 (0.51, 0.86)], and light-intensity physical activity [0.66 (0.51, 0.85)] had lower adjusted HRs (95% CIs) for VTE than those of participants in the lowest level. Both the total volumes of physical activity and light-intensity physical activity were negatively associated with VTE risk in participants with low, intermediate, and high PRS. However, moderate-to-vigorous-intensity physical activity was only protective against VTE in participants with low and intermediate PRS, with a significant interaction (P for interaction = 0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher levels of physical activity of any intensity were associated with a lower risk of new-onset VTE. However, the negative association between moderate-to-vigorous-intensity physical activity and new-onset VTE was significant only in participants with low and intermediate genetic predispositions to VTE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae273","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T07:39:28Z","timestamp":1724053168000},"page":"65-74","source":"Crossref","is-referenced-by-count":8,"title":["Accelerometer-measured intensity-specific physical activity, genetic predisposition, and the risk of venous thromboembolism: a cohort study"],"prefix":"10.1093","volume":"32","author":[{"given":"Rui","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University , No. 36, San Hao Street, Shenyang, Liaoning, 110004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Yang","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease , Shengjing Hospital of China Medical University, Shenyang ,","place":["China"]},{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University , No. 36, San Hao Street, Shenyang, Liaoning, 110004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ji","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease , Shengjing Hospital of China Medical University, Shenyang ,","place":["China"]},{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-4236","authenticated-orcid":false,"given":"Liangkai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease , Shengjing Hospital of China Medical University, Shenyang ,","place":["China"]},{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University , No. 36, San Hao Street, Shenyang, Liaoning, 110004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-1592","authenticated-orcid":false,"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease , Shengjing Hospital of China Medical University, Shenyang ,","place":["China"]},{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2025010600142550700_zwae273-B1","author":"Centers for Disease Control and Prevention (CDC)","year":"2021"},{"key":"2025010600142550700_zwae273-B2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/aje\/kwi309","article-title":"Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism","volume":"162","author":"Glynn","year":"2005","journal-title":"Am J Epidemiol"},{"key":"2025010600142550700_zwae273-B3","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1001\/archinte.164.20.2260","article-title":"Venous thromboembolism according to age: the impact of an aging population","volume":"164","author":"Stein","year":"2004","journal-title":"Arch Intern 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