{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:32:45Z","timestamp":1761611565914,"version":"build-2065373602"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Central apnoea (CA) and obstructive apnoea (OA) are highly prevalent in patients with chronic heart failure (HF), and transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized HF aetiology. This study aims to investigate the prevalence and impact of CA and OA in patients with ATTR-CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Consecutive patients with ATTR-CA who underwent 24\u2005h ambulatory cardiorespiratory monitoring were enlisted for an evaluation of the prevalence and severity of breathing disorders. The severity of these disorders was quantified using the apnoea\u2013hypopnoea index (AHI). Accordingly, the patients were categorized as having normal breathing (NB, AHI &amp;lt;5 events\/h), OA (AHI \u22655 events\/h with &amp;gt;50% being obstructive), or CA (AHI &amp;gt;5 events\/h with \u226550% being central). The primary endpoint at follow-up was all-cause mortality. Out of 142 patients enrolled (n = 142, aged 77 \u00b1 7 years, 91% males, 96% wild-type ATTR-CA), considering the 24\u2005h monitoring, 20% had NB (39% at daytime and 8% at nighttime), 35% had CA (45% at daytime and 39% at nighttime), and 45% had OA (25% at daytime and 54% at nighttime). After a median 2.3-year (1.4\u20133.3 years) follow-up, 24\u2005h, daytime, and nighttime AHIs were higher in non-survivors vs. survivors (all P &amp;lt; 0.05), independently of the prevalent apnoea type (P = 0.64). At multivariable regression analysis (adjusted for the possible clinical, echocardiographic, and biohumoral confounders), nighttime AHI \u226530 events\/h {hazard ratio 2.37 [95% confidence interval (CI) 1.07\u20135.23], P = 0.033} and high-sensitivity troponin T [hazard ratio 2.43 (95% CI 1.42\u20134.17), P = 0.001] were predictors of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both CA and OA are highly prevalent, both at daytime and nighttime, in patients with ATTR-CA and are associated with higher mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae297","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:15:38Z","timestamp":1726816538000},"page":"1461-1469","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and prognostic significance of central and obstructive apnoeas in patients with transthyretin cardiac amyloidosis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-3748","authenticated-orcid":false,"given":"Francesco","family":"Gentile","sequence":"first","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0, 56127 Pisa ,","place":["Italy"]},{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Giannoni","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0, 56127 Pisa ,","place":["Italy"]},{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Aimo","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0, 56127 Pisa ,","place":["Italy"]},{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-2328","authenticated-orcid":false,"given":"Vincenzo","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0, 56127 Pisa ,","place":["Italy"]},{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Iudice","sequence":"additional","affiliation":[{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Degl\u2019Innocenti","sequence":"additional","affiliation":[{"name":"Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. 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