{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:39:26Z","timestamp":1781804366419,"version":"3.54.5"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"grants","award":["R01 HL128526"],"award-info":[{"award-number":["R01 HL128526"]}]},{"name":"grants","award":["R01 HL162828"],"award-info":[{"award-number":["R01 HL162828"]}]},{"name":"grants","award":["U01 HL160226"],"award-info":[{"award-number":["U01 HL160226"]}]},{"name":"grants","award":["W81XWH2210245"],"award-info":[{"award-number":["W81XWH2210245"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL164901"],"award-info":[{"award-number":["K23HL164901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The effects of obesity on Fontan haemodynamics are poorly understood. Accordingly, we assessed its impact on exercise invasive haemodynamics and exercise capacity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Seventy-seven adults post-Fontan undergoing exercise cardiac catheterization (supine cycle protocol) were retrospectively identified using an institutional database and categorized according to the presence of obesity [body mass index (BMI) &amp;gt; 30\u2005kg\/m2] and overweight\/normal BMI (BMI \u2264 30\u2005kg\/m2). There were 18 individuals with obesity (BMI 36.4 \u00b1 3\u2005kg\/m2) and 59 with overweight\/normal BMI (BMI 24.1 \u00b1 3.6\u2005kg\/m2). Peak oxygen consumption (VO2) on non-invasive cardiopulmonary exercise testing was lower in patients with obesity (15.6 \u00b1 3.5 vs. 19.6 \u00b1 5.8\u2005mL\/kg\/min, P = 0.04). At rest, systemic flow (Qs) [7.0 (4.8; 8.3) vs. 4.8 (3.9; 5.8) L\/min, P = 0.001], pulmonary artery (PA) pressure (16.3 \u00b1 3.5 vs. 13.1 \u00b1 3.5\u2005mmHg, P = 0.002), and PA wedge pressure (PAWP) (11.7 \u00b1 4.4 vs. 8.9 \u00b1 3.1\u2005mmHg, P = 0.01) were higher, while arterial O2 saturation was lower [89.5% (86.5; 92.3) vs. 93% (90; 95)] in obesity compared with overweight\/normal BMI. Similarly, patients with obesity had higher exercise PA pressure (29.7 \u00b1 6.5 vs. 24.7 \u00b1 6.8\u2005mmHg, P = 0.01) and PAWP (23.0 \u00b1 6.5 vs. 19.8 \u00b1 7.3\u2005mmHg, P = 0.047), but lower arterial O2 saturation [82.4 \u00b1 7.0% vs. 89% (85; 92), P = 0.003].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adults post-Fontan with obesity have worse aerobic capacity, increased Qs, higher filling pressures, and decreased arterial O2 saturation compared with those with overweight\/normal BMI, both at rest and during exercise, mirroring the findings observed in the obesity phenotype of heart failure with preserved ejection fraction. Whether treating obesity and its cardiometabolic sequelae in Fontan patients will improve haemodynamics and outcomes requires further study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae314","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T12:57:37Z","timestamp":1727528257000},"page":"221-230","source":"Crossref","is-referenced-by-count":8,"title":["Fontan haemodynamics in adults with obesity compared with overweight and normal body mass index: a retrospective invasive exercise study"],"prefix":"10.1093","volume":"32","author":[{"given":"Derek N","family":"Opp","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Charles","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C","family":"Egbe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-0596","authenticated-orcid":false,"given":"Barry A","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh V","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-3065","authenticated-orcid":false,"given":"Kyla M","family":"Lara-Breitinger","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 First St SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Cordina","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Prince Alfred Hospital , 100 Carillon Ave, Newtown, NSW 2042 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-8474","authenticated-orcid":false,"given":"William 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