{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:57:22Z","timestamp":1781938642681,"version":"3.54.5"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"HELIUS"},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2010T084"],"award-info":[{"award-number":["2010T084"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"publisher","award":["200500003"],"award-info":[{"award-number":["200500003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Integration Fund","award":["2013EIF013"],"award-info":[{"award-number":["2013EIF013"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["278901"],"award-info":[{"award-number":["278901"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) are measures of autonomic cardiac control and are associated with hypertension. However, their value in predicting new-onset hypertension and changes in systolic blood pressure (SBP) remains elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We used longitudinal data of participants with and without a history of cardiovascular disease from the HEalthy Life In an Urban Setting (HELIUS) study. A non-invasive continuous finger blood pressure measurement at baseline was used to calculate xBRS and HRV. In normotensives at baseline, we calculated the odds ratio (OR) of developing hypertension at follow-up. In the full cohort, we assessed the change in SBP between baseline and follow-up using linear regression. Subgroup analyses were performed in the younger (&amp;lt;50 years) and older (\u226550 years) participants. Median follow-up was 6.6 years (interquartile range 5.8\u20137.4). A 50% lower xBRS at baseline was independently associated with a 1.31 higher OR [95% confidence interval (CI) 1.09\u20131.57] of developing hypertension at follow-up. No significant associations between the standard deviation of the normal-to-normal interval (SDNN) or the square root of the mean of successive differences between adjacent normal-to-normal intervals (RMSSD), and new-onset hypertension were found. Compared to the lowest tertile, an xBRS in the highest tertile was associated with a 3.61\u2005mmHg (95% CI 2.50\u20134.71) higher increase in SBP over time, whereas this was 1.11\u2005mmHg (95% CI 0.12\u20132.09) and 1.76\u2005mmHg (95% CI 0.73\u20132.79) for SDNN and RMSSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the general population, a lower xBRS is associated with increased odds of developing hypertension, and a steeper increase in SBP over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf011","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T07:16:24Z","timestamp":1736838984000},"page":"1116-1124","source":"Crossref","is-referenced-by-count":2,"title":["Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HELIUS study"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-1498","authenticated-orcid":false,"given":"Thomas A","family":"Bouwmeester","sequence":"first","affiliation":[{"name":"Department Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-9404","authenticated-orcid":false,"given":"Esther M C","family":"Vriend","sequence":"additional","affiliation":[{"name":"Department Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-3465","authenticated-orcid":false,"given":"Henrike","family":"Galenkamp","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-2461","authenticated-orcid":false,"given":"Berend E","family":"Westerhof","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Westerhof Cardiovascular Research , Amstelveen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-8751","authenticated-orcid":false,"given":"Didier","family":"Collard","sequence":"additional","affiliation":[{"name":"Department Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-4393","authenticated-orcid":false,"given":"Bert-Jan H","family":"van den Born","sequence":"additional","affiliation":[{"name":"Department Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam 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