{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:43:53Z","timestamp":1784029433829,"version":"3.55.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mamoma Foundation Fellowship"},{"DOI":"10.13039\/501100002996","name":"Heart Foundation Vanguard","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008717","name":"Sylvia & Charles Viertel Clinical Investigator","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008717","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wilma Beswick Fellowship"},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009930","name":"NHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHRMC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to define the association between severe coronary artery disease and widespread atherosclerosis in younger individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Individuals aged 1\u201350 years with sudden cardiac death (SCD) from 2019 to 2023, autopsy proven to be due to coronary artery disease, were identified using the state-wide EndUCD registry. The presence of extra-coronary atherosclerosis greater than modified American Heart Association Class III was assessed in five arterial beds (intra-cerebral vessels, aorta, and carotid, renal, and femoral arteries). A total of 3044 individuals experienced SCD; 356 were due to coronary artery disease and 64 (18.0%) had extra-coronary plaque. Plaque was identified in aorta (61\/356 patients, 17.1%), carotid arteries (9\/356, 2.5%), iliofemoral arteries (11\/356, 3.1%), intracerebral arteries (4\/153, 2.6%), and renal arteries (6\/356 patients, 1.7%). The only feature associated with extra-coronary plaque was older age (median 47.8 vs. 44.4 years, P = 0.0002). Patients with extra-coronary plaque had higher rates of cardiomegaly (67.2% vs. 50.7%, P = 0.022), cardiac fibrosis indicative of previous myocardial infarction (45.3% vs. 31.2%, P = 0.030), and multi-vessel coronary disease (72.6% vs. 55.6%, P = 0.014).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fewer than one in five people aged 1\u201350 years experiencing SCD from a coronary cause exhibit extra-coronary plaque, suggesting that in young people, severe atherosclerosis is not necessarily a systemic disease. This limits the utility of screening for carotid or aortic plaque to predict coronary atherosclerosis on an individual level. Individuals with extra-coronary plaque were older with more established coronary disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf032","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T23:20:08Z","timestamp":1737674408000},"page":"1729-1736","source":"Crossref","is-referenced-by-count":0,"title":["Minimal extra-cardiac atherosclerosis present in young people with sudden cardiac death due to coronary artery disease"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-9889","authenticated-orcid":false,"given":"Elizabeth D","family":"Paratz","sequence":"first","affiliation":[{"name":"HEART Lab, St Vincent\u2019s Institute of Medical Research , 9 Princes St, Fitzroy, VIC 3065 ,","place":["Australia"]},{"name":"HEART Lab, Victor Chang Cardiac Research Institute , 405 Liverpool St, Darlinghurst, NSW 2010 ,","place":["Australia"]},{"name":"Department of Cardiology, Alfred Hospital , 55 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,","place":["Australia"]},{"name":"School of Public Health and Preventive Medicine, Monash University , 553 St Kilda Rd, Melbourne 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-3643","authenticated-orcid":false,"given":"Andreas","family":"Pflaumer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Children\u2019s Hospital , 50 Flemington Rd, Parkville, Melbourne, VIC 3052 ,","place":["Australia"]},{"name":"Department of Paediatrics, University of Melbourne , Parkville, VIC 3010 ,","place":["Australia"]},{"name":"Department of Cardiology, Murdoch Children\u2019s Research Institute , 50 Flemington Rd, Parkville, Melbourne, VIC 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-2709","authenticated-orcid":false,"given":"Dion","family":"Stub","sequence":"additional","affiliation":[{"name":"Department 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