{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:03:13Z","timestamp":1792425793427,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Science","doi-asserted-by":"publisher","award":["CIFMS 2023-I2M-1-001"],"award-info":[{"award-number":["CIFMS 2023-I2M-1-001"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aims to evaluate the effect of Life\u2019s Essential 8 (LE8), a comprehensive cardiovascular health (CVH) metric from the American Heart Association, on the risk of cardiac conduction disorders (CCDs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a prospective cohort study of 112 160 adults from the UK Biobank, free of cardiovascular disease at baseline, to examine the association between LE8 scores and the risk of CCD. The LE8 scores were categorized into low (0\u201349), moderate (50\u201379), and high (80\u2013100) CVH groups. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CCD incidence during a median follow-up of 11.6 years. A total of 2760 CCD cases were identified. After adjustment for confounders, the high CVH group exhibited a significantly lower risk of CCD compared with the low CVH group (HR: 0.48, 95% CI: 0.40\u20130.56). Further analyses showed reduced risks for both severe conduction block (HR: 0.63, 95% CI: 0.51\u20130.78) and left bundle branch or fascicular block (HR: 0.35, 95% CI: 0.25\u20130.49) in the high CVH group. Restricted cubic spline regression revealed an L-shaped association between LE8 score and CCD risk. Among individual LE8 metrics, weighted quantile sum analysis revealed that body mass index (BMI) and sleep health were the major contributors to reduced CCD risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher LE8 scores were associated with a lower risk of CCD, including severe conduction block requiring pacemaker implantation and left bundle branch or fascicular block. Comprehensive strategies targeting optimal CVH, especially BMI and sleep health, may be beneficial for preventing CCD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf089","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T17:17:30Z","timestamp":1740071850000},"source":"Crossref","is-referenced-by-count":4,"title":["Association of Life\u2019s Essential 8 and incident cardiac conduction disorder: a prospective cohort study"],"prefix":"10.1093","author":[{"given":"Tianxin","family":"Long","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 Bei Li Shi Rd, Xicheng District, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University Fifth School of Clinical Medicine, National Center of Gerontology, Beijing Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 Bei Li Shi Rd, Xicheng District, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-0826","authenticated-orcid":false,"given":"Sijing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 Bei Li Shi Rd, Xicheng District, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 Bei Li Shi Rd, Xicheng District, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-4741","authenticated-orcid":false,"given":"Hongxia","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 Bei Li Shi Rd, Xicheng District, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6921-9375","authenticated-orcid":false,"given":"Wei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital , No. 167 Bei Li Shi Rd, Xicheng District, Beijing 100037 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