{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:32Z","timestamp":1787008772911,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the relationship between socioeconomic status, plaque burden on coronary computed tomography angiography (CCTA), management and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a post-hoc analysis of a multicentre randomised control trial, we assessed associations between socioeconomic status and qualitative (stenosis, adverse plaque characteristics) and quantitative (total plaque, calcified plaque, non-calcified and low attenuation) CCTA plaque features and examined the interaction of socioeconomic status on cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Socioeconomic status was available in 3948 participants of whom 1989 were randomised to CCTA and 1629 scans were suitable and available for quantitative plaque analysis. Within these 1629 participants, 15% were from the lowest socioeconomic quintile and 25% from the highest socioeconomic quintile. Participants in the most deprived socioeconomic group were younger, had lower cardiovascular risk, and less likely to have severe stenosis or multivessel disease. After adjustment for cardiovascular risk factors, there was no difference in quantitative plaque burden between socioeconomic groups. After a median of 4.75 years follow-up, CTCA-guided management was associated with similar changes in medical therapy, and similar reductions in the risk of coronary heart disease death, or non-fatal myocardial infarction in low and high socioeconomic groups, with no difference between the base and interaction models (p=0.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Socioeconomic status is not an independent predictor of coronary artery disease severity, rather, the association is mostly determined by modifiable risk factors. Preventive therapies, guided by CCTA, achieves similar benefits in both low and high socioeconomic status individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf121","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T15:24:20Z","timestamp":1741015460000},"source":"Crossref","is-referenced-by-count":7,"title":["Socioeconomic status, cardiovascular risk factors and coronary atherosclerosis: a SCOT-HEART trial analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5842-842X","authenticated-orcid":false,"given":"Jonathan R","family":"Weir-McCall","sequence":"first","affiliation":[{"name":"Department of Radiology, School of Medicine, University of Cambridge , Cambridge ,","place":["UK"]},{"name":"Department of Radiology, Royal Papworth Hospital , Cambridge ,","place":["UK"]},{"name":"Departments of Cardiology and Radiology, Royal Brompton Hospital, Guys and St. Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]},{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Wereski","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, University of Cambridge , Cambridge ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, University of Cambridge , Cambridge ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kwiecinski","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Angiology, Institute of Cardiology , Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D","family":"Adamson","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0533-7991","authenticated-orcid":false,"given":"Nicholas L","family":"Mills","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Tzolos","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-8636","authenticated-orcid":false,"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Roditi","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J R","family":"van Beek","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]},{"name":"Edinburgh Imaging Facility QMRI, University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J","family":"Shaw","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Centre , New York ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D","family":"Nicol","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Radiology, Royal Brompton Hospital, Guys and St. Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]},{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Centre , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-938X","authenticated-orcid":false,"given":"Piotr J","family":"Slomka","sequence":"additional","affiliation":[{"name":"Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Centre , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R","family":"Dweck","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-6970","authenticated-orcid":false,"given":"Damini","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Centre , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-5483","authenticated-orcid":false,"given":"Ahmed A","family":"Tawakol","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center Massachusetts General Hospital & Harvard Medical School \u00a0 Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Newby","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-2428","authenticated-orcid":false,"given":"Michelle C","family":"Williams","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence, University of Edinburgh , Edinburgh ,","place":["United Kingdom"]},{"name":"Edinburgh Imaging Facility QMRI, University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,5]]},"container-title":["European Journal of 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