{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:19:48Z","timestamp":1787789988703,"version":"build-2784847793"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypertension increases with age, with a very high prevalence in older patients. Since hypertension is a major contributor of cardiovascular diseases, this condition accounts for the majority of stroke and a relevant number of coronary artery disease cases in the older adults. Ageing is associated with frailty and multi-morbidity, often associated with poly-pharmacy, which may complicate the management of hypertension. Specific diseases like diabetes and Parkinson disease associated with autonomic dysfunctions, and the frail condition, should be carefully considered in order to avoid orthostatic hypotension. Aortic stenosis, cardiac hypertrophy, heart failure, reduced glomerular filtration rate, arrhythmias such as atrial fibrillation, obstructive coronaropathies, and cerebral vascular lesions constitute haemodynamic challenges and may be associated with increased adverse effects during anti-hypertensive treatments. Moreover, specific drugs and drug\u2013drug interactions are associated with side-effects particularly deleterious in the older patients. The worsening of the state of health and the increase in the degree of frailty can result either as a consequence of target organ damage related to hypertension or caused by anti-hypertensive drugs. Therefore, in the older adults, a careful assessment of the individual risk\/benefit profile and a personalized view of the patient are necessary to establish the appropriate blood pressure targets and the appropriate treatments.<\/jats:p>","DOI":"10.1093\/eurjpc\/zwaf194","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T18:27:28Z","timestamp":1744050448000},"page":"iii44-iii51","source":"Crossref","is-referenced-by-count":3,"title":["Hypertension management in the elderly and the very elderly"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-4864","authenticated-orcid":false,"given":"Luigina","family":"Guasti","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria , Via Guicciardini 5, 21100 Varese ,","place":["Italy"]},{"name":"Division of Geriatrics and Clinical Gerontology, ASST-Settelaghi , 21100 Varese ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Derosa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia , 27100 Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-3875","authenticated-orcid":false,"given":"Stefano","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence and AOU Careggi , 50134 Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-2433","authenticated-orcid":false,"given":"Marc","family":"Ferrini","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Pathology, CH Saint Joseph and Saint Luc , 69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-7228","authenticated-orcid":false,"given":"Riccardo","family":"Asteggiano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria , Via Guicciardini 5, 21100 Varese ,","place":["Italy"]},{"name":"Cardiology, Poliambulatori Gruppo LARC-Laboratorio Analisi e Ricerca Clinica , 10100 Turin ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"2026082619515640000_zwaf194-B1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1161\/HYPERTENSIONAHA.111.177766","article-title":"Historical trends and milestones in hypertension research: a model of the process of translational research","volume":"58","author":"Kotchen","year":"2011","journal-title":"Hypertension"},{"key":"2026082619515640000_zwaf194-B2","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease And Stroke Statistics: a report of US and global data from the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"2026082619515640000_zwaf194-B3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/eurjpc\/zwaa167","article-title":"Frailty in cardiology: definition, assessment and clinical implications for general cardiology. 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