{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:49:04Z","timestamp":1775069344221,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008868","name":"Jiangsu Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["BE2022828"],"award-info":[{"award-number":["BE2022828"]}],"id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2016YFC1305700"],"award-info":[{"award-number":["2016YFC1305700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"William T Southcott Senior Research Fellowship"},{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Current hypertension guidelines fail to discriminate between fasting and postprandial blood pressure (BP) measurements. Meal ingestion often triggers a marked increase in splanchnic blood flow, potentially inducing a sustained fall in systolic BP of \u226520\u2005mmHg, termed postprandial hypotension (PPH). This study aimed to evaluate BP responses to a 75\u2005g glucose drink and its implications for detecting hypertension and PPH in community-dwelling adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A stratified multi-stage random sampling method was used to obtain a nationally representative sample of n = 4429 adult residents between April 2020 and January 2021 in China. BP and heart rate (HR) were measured before, and 1 and 2\u2005h after, a 75\u2005g glucose drink. When fasting, 38.4% of the study population had high BP (BP \u2265140\/90\u2005mmHg). Following the glucose drink, SBP and DBP decreased (SBP by 6.2 [95% CI: 5.8, 6.6] mmHg and 8.1 [7.7, 8.5] mmHg, DBP by 4.7 [4.4, 4.9] mmHg and 6.1 [5.8, 6.4] mmHg), and HR increased (by 4.3 [4.0, 4.5] bpm and 2.6 [2.4, 2.9] bpm) at 1 and 2\u2005h (P &amp;lt; 0.001 for all), with only 30.9% and 27.0% of the study population having high BP at 1 and 2\u2005h, respectively. After adjustment for age and sex distribution, 19.9% of the general population was estimated to have PPH. Postprandial hypotension was associated with an increased risk of combined cardiovascular disease and stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Ingestion of a 75\u2005g glucose drink often lowers BP, frequently leading to PPH and influencing the detection of hypertension. Accordingly, guidelines for measurements of BP and interpretation of outcomes should consider the potential impact of meal ingestion on BP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf217","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T12:59:58Z","timestamp":1744117198000},"page":"1382-1391","source":"Crossref","is-referenced-by-count":3,"title":["Variations in blood pressure after a 75\u2005g oral glucose load and their implications for detecting hypertension and postprandial hypotension in Chinese adults: a cross-sectional study"],"prefix":"10.1093","volume":"32","author":[{"given":"Xiaoying","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University , 87 Ding Jia Qiao, Nanjing 210009, Jiangsu 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,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanhu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of General Practice, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University , Nanjing, Jiangsu ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-0933","authenticated-orcid":false,"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Southeast University , Nanjing, Jiangsu ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Integrated Services, Jiangsu Provincial Center for Disease Control and Prevention , Nanjing, Jiangsu 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,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Kunming Medical University , Kunming, Yunnan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjie","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, Diabetes Research Institute of Fujian Province , Fuzhou, Fujian 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