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We aimed to develop a new model, CArdiovascular Risk Estimation\u2014Diabetes Mellitus (CARE-DM), to predict the risk of cardiovascular disease (CVD) in older adults with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We developed a model to predict the risk of incident CVD in participants aged \u226565 years with diabetes using data from four population-based prospective cohorts, accounting for the competing risk of non-cardiovascular death. Pre-specified predictors were age, gender, smoking status, alcohol consumption, body mass index, total and HDL cholesterol, use of antihypertensive, cholesterol-lowering and glucose-lowering medication, diabetes duration, and glycated haemoglobin. We assessed model performance using measures of calibration and discrimination. We used a 10-fold cross-validation and a bootstrapping approach to correct estimates for optimism and conducted an internal\u2013external cross-validation. A total of 6943 participants (median age 72 years, 56% women) with diabetes were included in the model development. Over a median follow-up of 6.3 (interquartile range 3.7, 7.2) years, 1204 (17.3%) participants experienced a CVD event. Internal validation with optimism correction showed adequate model performance with a C-index of 0.65 (95% confidence interval 0.63\u20130.67), an observed-to-expected ratio of 1.01 (0.95\u20131.08), and a calibration slope of 1.13 (0.95\u20131.31) at 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The new CARE-DM model allows prediction of the incident CVD risk in older adults with type 2 diabetes. Independent external validation should be conducted to confirm the model\u2019s performance before implementation in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf296","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T08:07:04Z","timestamp":1747123624000},"page":"44-52","source":"Crossref","is-referenced-by-count":5,"title":["Development and validation of the CARE-DM model to predict the cardiovascular risk in older persons with type 2 diabetes"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-0182","authenticated-orcid":false,"given":"Valerie","family":"Aponte Ribero","sequence":"first","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , Mittelstrasse 43, Bern 3012 ,","place":["Switzerland"]},{"name":"Graduate School for Health Sciences, University of Bern , Mittelstrasse 43, Bern 3012 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San Francisco , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-8093","authenticated-orcid":false,"given":"S\u00e9verine","family":"Henrard","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy & Pharmacoepidemiology Research Group, Louvain Drug Research Institute (LDRI), Universit\u00e9 catholique de Louvain , Brussels 1200 ,","place":["Belgium"]},{"name":"Institute of Health and Society (IRSS), Universit\u00e9 catholique de Louvain , Brussels 1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Waeber","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne , Lausanne 1011 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