{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:15:13Z","timestamp":1793067313548,"version":"4.5.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Medical Center of the Johannes Gutenberg University"},{"name":"German Federal Ministry of Education and Research","award":["01EO1003"],"award-info":[{"award-number":["01EO1003"]}]},{"name":"German Federal Ministry of Education and Research","award":["01EO1503"],"award-info":[{"award-number":["01EO1503"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>It has not been conclusively established whether and to what extent pulmonary embolism (PE) affects health-related quality of life (HrQoL). We aimed to assess the long-term independent association of PE with HrQoL to provide reference values for interventional studies and support quantification of the burden of PE in terms of quality- or disability-adjusted life years (QALYs and DALYs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 1005 patients from a prospective multicenter study, followed 3 and 12 months after PE, were successfully matched to 3058 individuals from the general population of the same country based on age, sex, and key comorbidities. Differences between acute PE survivors and matched controls in the ordinal EQ-5D-5L HrQoL dimensions were assessed using multivariable ordinal regression, in the HrQoL index (reflecting overall HrQoL) using multivariable-adjusted mixed linear regression. Both multiple imputation and complete case analysis were performed. Compared with controls, patients reported worse HrQoL in the dimensions self-care, usual activities, and anxiety\/depression, and worse HrQoL index at both 3 [adjusted difference \u22120.04 (95% CI: \u22120.06, \u22120.039) in a range from 0 to 1] and 12 months [\u22120.02 (95% CI: \u22120.04, \u22120.01)] in the imputation analysis. Complete case analysis showed similar results. The annual disability weight of PE for DALY calculation was conservatively estimated at 0.03 (95% CI: 0.02, 0.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PE was independently associated with a moderate decrease in HrQoL, which persisted 12 months after the acute episode despite partial recovery over time. This degree of impairment is comparable to that imposed by several other cardiopulmonary diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf307","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:52:02Z","timestamp":1747036322000},"page":"1506-1514","source":"Crossref","is-referenced-by-count":13,"title":["Burden and long-term impact of pulmonary embolism on health-related quality of life: a matched cohort study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-0724","authenticated-orcid":false,"given":"Luca","family":"Valerio","sequence":"first","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]},{"name":"Department of Cardiology, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-7989","authenticated-orcid":false,"given":"Thomas","family":"Grochtdreis","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-2859","authenticated-orcid":false,"given":"Anna C","family":"Mavromanoli","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0586-6386","authenticated-orcid":false,"given":"Ioannis T","family":"Farmakis","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]},{"name":"Department of Cardiology, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-0587","authenticated-orcid":false,"given":"Christina","family":"Abele","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-9064","authenticated-orcid":false,"given":"Thomas","family":"Neusius","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]},{"name":"Wiesbaden Business School, RheinMain University of Applied Sciences , Wiesbaden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5718-0549","authenticated-orcid":false,"given":"Katharina","family":"Mohr","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]},{"name":"Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-9212","authenticated-orcid":false,"given":"Konstantinos C","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-0366","authenticated-orcid":false,"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]},{"name":"Department of Cardiology, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-9584","authenticated-orcid":false,"given":"Karsten","family":"Keller","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]},{"name":"Department of Cardiology, University Medical Center of the Johannes Gutenberg University , Langenbeckstr. 1, 55116 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2605-3456","authenticated-orcid":false,"given":"Alexander","family":"Konnopka","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2618-347X","authenticated-orcid":false,"given":"Stefano","family":"Barco","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg 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