{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:05:28Z","timestamp":1792479928781,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) affects 5\u201320% of reproductive-aged women and is linked to cardiovascular risk factors and atherosclerosis. Yet, its long-term association with atherosclerotic cardiovascular disease remains uncertain and will be the focus of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Women diagnosed with PCOS (1995\u20132024) were identified through Danish nationwide registries and matched 1:4 with female controls from the background population by age and year of index. The primary outcome was a composite of acute myocardial infarction and ischaemic stroke, with the individual components serving as secondary outcomes. The study included 25 513 women with PCOS and 102 052 matched controls (median age 29.9 years). Women with PCOS had a higher prevalence of cardiovascular risk factors compared with controls. The 25-year cumulative incidence of the composite outcome was higher in women with PCOS [3.4% (95% confidence interval (CI) 2.8\u20134.2%)] compared with controls [2.0% (95% CI 1.8\u20132.3%)]. In Cox regression analyses, PCOS was associated with an increased risk of the composite outcome [unadjusted hazard ratio (HR) 1.82 (95% CI 1.56\u20132.11), adjusted HR 1.53 (95% CI 1.30\u20131.81)], acute myocardial infarction [unadjusted HR 1.86 (95% CI 1.45\u20132.39), adjusted HR 1.58 (95% CI 1.21\u20132.07)], and ischaemic stroke [unadjusted HR 1.83 (95% CI 1.52\u20132.22), adjusted HR 1.56 (95% CI 1.27\u20131.91)]. The associations did not vary by use of oral contraception, metformin, anti-androgens, spironolactone, or glucagon-like peptide (GLP)-1 analogues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women with PCOS were at increased associated risk of acute myocardial infarction and ischaemic stroke compared with controls. While absolute risks were low, these findings highlight the potential benefits of early cardiovascular risk assessment and preventive strategies in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf351","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T07:45:43Z","timestamp":1749887143000},"page":"2444-2451","source":"Crossref","is-referenced-by-count":8,"title":["Polycystic ovarian syndrome and long-term risk of acute myocardial infarction and ischaemic stroke"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-4189","authenticated-orcid":false,"given":"Eva","family":"Havers-Borgersen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Zealand University Hospital , 4000 Roskilde ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Rigshospitalet, Copenhagen University Hospital , 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille Fog","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Herlev & Gentofte Hospital , 2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie S","family":"Reinert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Vistisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawad H","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Zealand University Hospital , 4000 Roskilde ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-1467","authenticated-orcid":false,"given":"Lauge","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-2466","authenticated-orcid":false,"given":"Morten","family":"Schou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Herlev & Gentofte Hospital , 2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-4167","authenticated-orcid":false,"given":"Emil L","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"2026092119572263600_zwaf351-B1","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics\u20142023 update: a report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"2026092119572263600_zwaf351-B2","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1093\/eurheartj\/ehae466","article-title":"European Society of Cardiology: the 2023 atlas of cardiovascular disease statistics","volume":"45","author":"Timmis","year":"2024","journal-title":"Eur Heart J"},{"key":"2026092119572263600_zwaf351-B3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1385\/ENDO:30:1:45","article-title":"Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS","volume":"30","author":"Teede","year":"2006","journal-title":"Endocrine"},{"key":"2026092119572263600_zwaf351-B4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmq001","article-title":"Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"16","author":"Moran","year":"2010","journal-title":"Hum Reprod Update"},{"key":"2026092119572263600_zwaf351-B5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/humrep\/det469","article-title":"The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-M\u00fcllerian hormone","volume":"29","author":"Lauritsen","year":"2014","journal-title":"Hum Reprod"},{"key":"2026092119572263600_zwaf351-B6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr Rev"},{"key":"2026092119572263600_zwaf351-B7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ejendo\/lvae124","article-title":"Association of hyperandrogenaemia with hypertension and cardiovascular events in pre-menopausal women: a prospective population-based cohort study","volume":"191","author":"Tuorila","year":"2024","journal-title":"Eur J Endocrinol"},{"key":"2026092119572263600_zwaf351-B8","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1210\/clinem\/dgad590","article-title":"Hyperandrogenism and cardiometabolic risk in pre- and postmenopausal women\u2014what is the evidence?","volume":"109","author":"Hirschberg","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2026092119572263600_zwaf351-B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2026092119572263600_zwaf351-B11","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1161\/CIRCULATIONAHA.123.065827","article-title":"Polycystic ovary syndrome fuels cardiovascular inflammation and aggravates ischemic cardiac injury","volume":"148","author":"Gao","year":"2023","journal-title":"Circulation"},{"key":"2026092119572263600_zwaf351-B12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/1464727002000198781","article-title":"Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study","volume":"3","author":"Wild","year":"2000","journal-title":"Hum Fertil"},{"key":"2026092119572263600_zwaf351-B13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2265.2000.01000.x","article-title":"Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study","volume":"52","author":"Wild","year":"2000","journal-title":"Clin Endocrinol"},{"key":"2026092119572263600_zwaf351-B14","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.18632\/oncotarget.23985","article-title":"Coronary artery disease risk in young women with polycystic ovary syndrome","volume":"9","author":"Ding","year":"2018","journal-title":"Oncotarget"},{"key":"2026092119572263600_zwaf351-B15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12933-018-0680-5","article-title":"Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome","volume":"17","author":"Glintborg","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"2026092119572263600_zwaf351-B16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/humupd\/dmaa029","article-title":"Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis","volume":"26","author":"Wekker","year":"2020","journal-title":"Hum Reprod Update"},{"key":"2026092119572263600_zwaf351-B17","doi-asserted-by":"crossref","first-page":"E3369","DOI":"10.1210\/clinem\/dgab392","article-title":"Women with polycystic ovary syndrome have an increased risk of major cardiovascular events: a population study","volume":"106","author":"Berni","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/ejendo\/lvad067","article-title":"Association of polycystic ovary syndrome with cardiovascular disease among female hospitalizations in the United States","volume":"188","author":"Dwivedi","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"2026092119572263600_zwaf351-B19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ejendo\/lvad077","article-title":"Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria\u2014a prospective population-based cohort study","volume":"189","author":"Ollila","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"2026092119572263600_zwaf351-B20","first-page":"1","article-title":"Risk and incidence of cardiovascular disease associated with polycystic ovary syndrome","volume":"31","author":"Wan","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"2026092119572263600_zwaf351-B21","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1210\/jc.2005-2430","article-title":"Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome","volume":"91","author":"Lo","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/GME.0b013e31802cc7ab","article-title":"Searching for polycystic ovary syndrome in postmenopausal women: evidence of a dose-effect association with prevalent cardiovascular disease","volume":"14","author":"Krentz","year":"2007","journal-title":"Menopause"},{"key":"2026092119572263600_zwaf351-B23","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1210\/jc.2011-1677","article-title":"Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study","volume":"96","author":"Schmidt","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B24","first-page":"74","article-title":"Risk of cardiovascular events in patients with polycystic ovary syndrome","volume":"70","author":"Iftikhar","year":"2012","journal-title":"Neth J Med"},{"key":"2026092119572263600_zwaf351-B25","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jc.2014-3886","article-title":"The potential implications of a PCOS diagnosis on a woman\u2019s long-term health using data linkage","volume":"100","author":"Hart","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1530\/EJE-14-1108","article-title":"Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome","volume":"172","author":"Glintborg","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"2026092119572263600_zwaf351-B27","doi-asserted-by":"crossref","first-page":"33715","DOI":"10.18632\/oncotarget.9553","article-title":"Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"2026092119572263600_zwaf351-B28","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1210\/jc.2017-02421","article-title":"High androgens in postmenopausal women and the risk for atherosclerosis and cardiovascular disease: the Rotterdam study","volume":"103","author":"Meun","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11886-024-02050-5","article-title":"Polycystic ovary syndrome, insulin resistance, and cardiovascular disease","volume":"26","author":"Dubey","year":"2024","journal-title":"Curr Cardiol Rep"},{"key":"2026092119572263600_zwaf351-B30","doi-asserted-by":"crossref","first-page":"552421","DOI":"10.3389\/fcvm.2020.552421","article-title":"Risk of cardiovascular and cerebrovascular events in polycystic ovarian syndrome women: a meta-analysis of cohort studies","volume":"7","author":"Zhang","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"2026092119572263600_zwaf351-B31","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/heartjnl-2018-314268","article-title":"Unique cardiovascular risk factors in women","volume":"105","author":"Young","year":"2019","journal-title":"Heart"},{"key":"2026092119572263600_zwaf351-B32","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1210\/jc.2011-2935","article-title":"Uncertainty remains in women with PCOS regarding the increased incidence of cardiovascular disease later in life, despite the indisputable presence of multiple cardiovascular risk factors at a young age","volume":"96","author":"Fauser","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2026092119572263600_zwaf351-B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm13030698","article-title":"Possible effect of polycystic ovary syndrome (PCOS) on cardiovascular disease (CVD): an update","volume":"13","author":"Profili","year":"2024","journal-title":"J Clin Med"},{"key":"2026092119572263600_zwaf351-B34","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.fertnstert.2022.03.009","article-title":"Polycystic ovary syndrome: a \u201crisk-enhancing\u201d factor for cardiovascular disease","volume":"117","author":"Guan","year":"2022","journal-title":"Fertil Steril"},{"key":"2026092119572263600_zwaf351-B35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Heal"},{"key":"2026092119572263600_zwaf351-B36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish National Patient Registry: a review of content, data quality, and research potential","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin Epidemiol"},{"key":"2026092119572263600_zwaf351-B37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand J Public Heal"},{"key":"2026092119572263600_zwaf351-B38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1403494811399958","article-title":"The Danish Register of Causes of Death","volume":"39","author":"Helweg-Larsen","year":"2011","journal-title":"Scand J Public Health"},{"key":"2026092119572263600_zwaf351-B39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry","volume":"39","author":"Wallach Kildemoes","year":"2011","journal-title":"Scand J Public Health"},{"key":"2026092119572263600_zwaf351-B40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1403494811405098","article-title":"Danish registers on personal income and transfer payments","volume":"39","author":"Baadsgaard","year":"2011","journal-title":"Scand J Public Heal"},{"key":"2026092119572263600_zwaf351-B41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1403494810394715","article-title":"Danish Education Registers","volume":"39","author":"Jensen","year":"2011","journal-title":"Scand J Public Heal"},{"key":"2026092119572263600_zwaf351-B42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.d124","article-title":"Validation of risk stratification schemes for predicting stroke nationwide cohort study","volume":"342","author":"Olesen","year":"2011","journal-title":"BMJ"},{"key":"2026092119572263600_zwaf351-B43","doi-asserted-by":"crossref","first-page":"e012832","DOI":"10.1136\/bmjopen-2016-012832","article-title":"Positive predictive value of cardiovascular diagnoses in the Danish National Patient Registry: a validation study","volume":"6","author":"Sundb\u00f8ll","year":"2016","journal-title":"BMJ Open"},{"key":"2026092119572263600_zwaf351-B44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijcard.2011.01.016","article-title":"The decline in coronary heart disease mortality is slowing in young adults (Australia 1976\u20132006): a time trend analysis","volume":"158","author":"O\u2019Flaherty","year":"2012","journal-title":"Int J Cardiol"},{"key":"2026092119572263600_zwaf351-B45","first-page":"219","article-title":"Coronary heart disease mortality among young adults in Scotland in relation to social inequalities: time trend study","volume":"339","author":"O\u2019Flaherty","year":"2009","journal-title":"BMJ"},{"key":"2026092119572263600_zwaf351-B46","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jacc.2007.05.056","article-title":"Coronary heart disease mortality among young adults in the U.S. From 1980 through 2002. Concealed leveling of mortality rates","volume":"50","author":"Ford","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026092119572263600_zwaf351-B47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-8-148","article-title":"Patterns of coronary heart disease mortality over the 20th century in England and Wales: possible plateaus in the rate of decline","volume":"8","author":"Allender","year":"2008","journal-title":"BMC Public Health"},{"key":"2026092119572263600_zwaf351-B48","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/1741826710389393","article-title":"Coronary heart disease and cerebrovascular disease mortality in young adults: recent trends in Europe","volume":"18","author":"Bertuccio","year":"2011","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2026092119572263600_zwaf351-B49","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1093\/eurheartj\/eht159","article-title":"Trends in age-specific coronary heart disease mortality in the European Union over three decades: 1980\u20132009","volume":"34","author":"Nichols","year":"2013","journal-title":"Eur Heart J"},{"key":"2026092119572263600_zwaf351-B50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1161\/CIRCULATIONAHA.115.015293","article-title":"Coronary heart disease mortality declines in the United States from 1979 through 2011 evidence for stagnation in young adults, especially women","volume":"132","author":"Wilmot","year":"2015","journal-title":"Circulation"},{"key":"2026092119572263600_zwaf351-B51","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030","volume":"397","author":"Vogel","year":"2021","journal-title":"Lancet"},{"key":"2026092119572263600_zwaf351-B52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj-2023-078523","article-title":"Trends in cardiovascular disease incidence among 22 million people in the UK over 20 years: population based study","volume":"385","author":"Conrad","year":"2024","journal-title":"BMJ"},{"key":"2026092119572263600_zwaf351-B53","first-page":"1","article-title":"Nonobese young females with polycystic ovary syndrome are at high risk for long-term cardiovascular disease","author":"Zhao","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"2026092119572263600_zwaf351-B54","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/humrep\/deaa371","article-title":"Measuring the global disease burden of polycystic ovary syndrome in 194 countries: global burden of disease study 2017","volume":"36","author":"Liu","year":"2021","journal-title":"Hum Reprod"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article-pdf\/doi\/10.1093\/eurjpc\/zwaf351\/64140516\/zwaf351.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/33\/13\/2444\/64140516\/zwaf351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/33\/13\/2444\/64140516\/zwaf351.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:57:34Z","timestamp":1790035054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/33\/13\/2444\/8238699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":54,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,8,30]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwaf351","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2025,8,30]]}}}