{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:28:19Z","timestamp":1791599299045,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Climbing Plan of Guangdong Provincial People\u2019s Hospital","award":["DFJH2020022"],"award-info":[{"award-number":["DFJH2020022"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial Enterprise Joint Fund","award":["2022A1515220113"],"award-info":[{"award-number":["2022A1515220113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While the association between diabetes and degenerative aortic valve stenosis (AS) is well established, the relationship between prediabetes and AS remains unclear, and the potential influence of genetic susceptibility on these associations has yet to be explored. We aimed to examine the association between hyperglycaemia, including prediabetes and diabetes, and incident degenerative AS and to explore whether genetic susceptibility modify these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This population-based cohort study analysed data from 461 017 UK Biobank participants who were divided into three groups (normoglycaemia, prediabetes, and type 2 diabetes) according to their baseline glycaemic status. The primary outcome was incident degenerative AS, while the secondary outcome was AS-related events, a composite outcome of AS-related intervention or death due to AS. During a median follow-up of 14.3 years, 5307 AS and 2209 AS-related events were documented. Compared with normoglycaemia, the adjusted HR (95% CI) for incident AS of prediabetes and diabetes were 1.21 (95% CI, 1.13\u20131.30) and 1.66 (95% CI, 1.52\u20131.80), respectively. The corresponding values for incident AS-related events were 1.26 (95% CI, 1.13\u20131.41) and 1.60 (95% CI, 1.40\u20131.83), respectively. For the joint associations, participants with prediabetes or diabetes had a higher risk of AS and AS-related events regardless of genetic risk and the highest hazard was observed in those with diabetes and high genetic risk (AS: HR, 3.25, 95% CI, 2.82\u20133.74; AS-related events: HR, 3.79, 95% CI, 3.05\u20134.72).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prediabetes, in addition to diabetes, was associated with an increased risk of AS and AS-related events, independent of a genetic risk score for AS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf355","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T07:56:34Z","timestamp":1750406194000},"page":"1753-1762","source":"Crossref","is-referenced-by-count":6,"title":["Hyperglycaemia and genetic susceptibility in relation to incident degenerative aortic valve stenosis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-0161","authenticated-orcid":false,"given":"Chaolei","family":"Chen","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Nursing, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqing","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]},{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"2025120401165382000_zwaf355-B1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global epidemiology of valvular heart disease","volume":"18","author":"Coffey","year":"2021","journal-title":"Nat Rev 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