{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:12:10Z","timestamp":1783980730292,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Radiofrequency (RF) renal denervation (RDN) safely lowers office and 24-h blood pressure (BP). This meta-analysis examined the long-term durability of RF RDN based on randomized trials and observational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with uncontrolled hypertension undergoing RF RDN using the Symplicity Flex\u2122 or Spyral\u2122 device and a minimum follow-up of 3 years were included. Key outcomes included office and 24-h BP change from baseline as well as changes in anti-hypertensive drugs. A random effects meta-analysis was conducted over 3 years, or the last reported follow-up beyond 3 years. A total of 2212 patients identified among 18 reports were evaluated for BP. The mean duration of follow-up was 4.4 years (range 3\u20139.4). The long-term reduction in office systolic BP from baseline in 15 reports (n = 2040) was \u221223.0\u2005mmHg (95% confidence interval: \u221226.8 to \u221219.1, P &amp;lt; 0.05) for the random effects model and \u221220.5 (\u221221.6 to \u221219.4) for the fixed effect model. Twenty-four-hour ambulatory systolic BP was available in 11 reports (n = 1018) and decreased significantly by \u221213.6\u2005mmHg (\u221216.5 to \u221210.8, P &amp;lt; 0.05). Fixed effect model results were similar. Diastolic office and 24-h BP paralleled these findings in both models. Nighttime systolic BP also decreased significantly by \u221214.2\u2005mmHg (\u221227.6 to \u22120.8, P &amp;lt; 0.05). The number of prescribed anti-hypertensive drugs and eGFR also decreased. Heart rate remained unchanged through the final follow-up in both models. Safety events were rare, with a mean rate of renal artery complications of 0.14% (0.08\u20130.20%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis comprising 18 studies demonstrated sustained and significant office and ambulatory BP reductions following Symplicity RDN through at least 3 years without an increase in anti-hypertensive medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf368","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T07:26:55Z","timestamp":1752823615000},"page":"1238-1247","source":"Crossref","is-referenced-by-count":7,"title":["Long-term outcomes following radiofrequency renal denervation: meta-analysis of 18 reports"],"prefix":"10.1093","volume":"33","author":[{"given":"Felix","family":"Mahfoud","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Basel , Petersgraben 4, 4031 Basel ,","place":["Switzerland"]},{"name":"Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel , Petersgraben 4, 4031 Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-6655","authenticated-orcid":false,"given":"David E","family":"Kandzari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Piedmont Heart Institute , Ste 2065, 95 Collier Rd NW, Atlanta, GA 30309 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus P","family":"Schlaich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dobney Hypertension Centre, Medical School\u2014Royal Perth Hospital Unit, The University of Western Australia , Level 3, MRF Bldg, Rear 50 Murray St, Perth, WA 6000 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland E","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen , Erlangen, 91054 Bavaria ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Lauder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Basel , Petersgraben 4, 4031 Basel ,","place":["Switzerland"]},{"name":"Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel , Petersgraben 4, 4031 Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ruilope","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario 12 de Octubre and CIBERCV and School of Doctoral Studies and Research, Universidad Europea de Madrid , Av. de C\u00f3rdoba, s\/n, Usera, 28041 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Narkiewicz","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Diabetology, Medical University of Gdansk , Marii Sk\u0142odowskiej-Curie 3a, 80-210 Gda\u0144sk ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College London and National Institute for Health Research University College London Hospitals Biomedical Research Centre , Maple House, 1st Floor, Suite A, 149 Tottenham Court Road, London W1T 7DN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-7740","authenticated-orcid":false,"given":"Douglas A","family":"Hettrick","sequence":"additional","affiliation":[{"name":"Department of Coronary and Renal Denervation, Medtronic PLC , 3576 Unocal Pl, Santa Rosa, CA 95403 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Hsin","family":"Lung","sequence":"additional","affiliation":[{"name":"Department of Coronary and Renal Denervation, Medtronic PLC , 3576 Unocal Pl, Santa Rosa, CA 95403 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-0304","authenticated-orcid":false,"given":"Flavio","family":"Ribichini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Azienda Ospedaliera Universitaria Integrata Verona , Piazzale Aristide Stefani, 1, 37126 Verona VR ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-6912","authenticated-orcid":false,"given":"Joachim","family":"Weil","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sana Kliniken L\u00fcbeck GmbH , Kronsforder Allee 71-73, 23560 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospital Galway and National University of Ireland Galway , Newcastle Rd, Galway H91 YR71 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-3176","authenticated-orcid":false,"given":"Giuseppe","family":"Mancia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Milano-Bicocca , Piazza dell'Ateneo Nuovo, 1, 20126 Milano MI ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e4tsklinikum des Saarlandes, Saarland University , Kirrberger Str. 100, 66421 Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"2026051513421711000_zwaf368-B1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"GBD 2019 Risk Factors Collaborators","year":"2020","journal-title":"Lancet"},{"key":"2026051513421711000_zwaf368-B2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/eurjpc\/zwad262","article-title":"Worldwide trends in 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