{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:08:56Z","timestamp":1775002136046,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Comorbidities play an important role in heart failure (HF) with preserved ejection fraction (HFpEF). Still, current guidelines lack clear directives for routine comorbidity screening and are primarily based on HF with reduced ejection fraction populations. This study evaluates the diagnostic yield of standardized routine workup for comorbidities in HFpEF. The goal is to provide clinicians with actionable insights to refine strategies for screening and managing HFpEF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This single-centre prospective observational cohort study included patients diagnosed with HFpEF via a specialized outpatient clinic and evaluated the diagnostic yield of standardized diagnostic workup for comorbidities, including laboratory testing, sleep apnoea screening, 24\u2005h Holter monitoring, spirometry, exercise testing, and 6\u2005min walk test. A total of 501 HFpEF patients (age 75 \u00b1 7 years, 67% female) were included. Before diagnostic workup, a median of three [2\u20135] comorbidities was known, and one additional comorbidity was diagnosed during standardized workup, most commonly sleep apnoea (33%) and iron deficiency (35%). Overall, the most prevalent comorbidities were hypertension (74%), sleep apnoea (52%), atrial fibrillation (50%), iron deficiency (49%), and obesity (45%). Pre-existing comorbidities did not receive optimal guideline-directed therapy, specifically diabetes (23%), hypercholesterolaemia (36%), and obesity (45%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the value of routine comorbidity screening in HFpEF, identifying one new comorbidity per patient on top of three pre-existing conditions, most commonly sleep apnoea or iron deficiency. Treatment of existing comorbidities was often suboptimal. Systematic screening not only improves the detection of undiagnosed conditions but also enables personalized and effective comorbidity management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf429","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:13:23Z","timestamp":1752128003000},"page":"276-285","source":"Crossref","is-referenced-by-count":3,"title":["The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population"],"prefix":"10.1093","volume":"33","author":[{"given":"Sanne G J","family":"Mourmans","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0763-7551","authenticated-orcid":false,"given":"Anouk","family":"Achten","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-3453","authenticated-orcid":false,"given":"Jerremy","family":"Weerts","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijne","family":"Scheepers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arantxa","family":"Barandiar\u00e1n Aizpurua","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-071X","authenticated-orcid":false,"given":"Michiel","family":"Henkens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]},{"name":"Department of Pathology, Maastricht University Medical Centre (MUMC+) , Maastricht ,","place":["The Netherlands"]},{"name":"Netherlands Heart Institute , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Uszko-Lencer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-8566","authenticated-orcid":false,"given":"Hans-Peter","family":"Brunner-La Rocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC+) , PO Box 5800, Maastricht 6202 AZ ,","place":["The 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