{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:19:26Z","timestamp":1793089166128,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009600"],"award-info":[{"award-number":["2022YFC2009600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009605"],"award-info":[{"award-number":["2022YFC2009605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973133"],"award-info":[{"award-number":["81973133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030022"],"award-info":[{"award-number":["82030022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330020"],"award-info":[{"award-number":["82330020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies R&D Program of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1111030004"],"award-info":[{"award-number":["2023B1111030004"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Provincial Clinical Research Center for Kidney Disease","award":["2020B1111170013"],"award-info":[{"award-number":["2020B1111170013"]}]},{"DOI":"10.13039\/501100012176","name":"Program of Introducing Talents of Discipline to Universities","doi-asserted-by":"publisher","award":["D18005"],"award-info":[{"award-number":["D18005"]}],"id":[{"id":"10.13039\/501100012176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to investigate the association between Life\u2019s Crucial 9 (LC9) and the risk of aortic stenosis and the mediating roles of plasma proteomics and inflammatory biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study analysed 295 828 UK Biobank participants (including 31 522 with available proteomics data) without aortic stenosis at baseline. Life\u2019s Crucial 9 score was categorized into three groups: low (0\u201349 points), moderate (50\u201379 points), and high (80\u2013100 points). Compared with participants in the low LC9 group, those in the moderate [hazard ratio (HR), 0.49; 95% confidence interval (CI), 0.44\u20130.55] and high groups (HR, 0.28; 95% CI, 0.23\u20130.34) had a significantly lower aortic stenosis risk. The population attributable risk for aortic stenosis risk associated with low\/moderate LC9 was 43.6% (95% CI, 34.1\u201353.0). A proteomic signature for LC9, consisting of 549 proteins, was constructed and found to be primarily involved in pathways related to lipid metabolism, immune function, and inflammation. The proteomic signature significantly mediated 35.9% of the association between LC9 and aortic stenosis risk, with adrenomedullin showing the highest mediating proportion at 20.9%, followed by fatty acid-binding protein 4 (18.6%), hepatocyte growth factor (17.3%), hepatitis A virus cellular receptor 1 (17.0%), and growth differentiation factor 15 (15.8%). Inflammatory biomarkers also mediated a small but significant proportion of LC9-related aortic stenosis risk, with mediating proportions ranging from 1.0 to 5.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher LC9 score was associated with reduced aortic stenosis risk. This inverse relationship was significantly mediated by plasma proteomics and inflammatory biomarkers. These findings underscore the importance of adherence to LC9 guidelines for the prevention of aortic stenosis and provide insights into the biological pathways linking cardiovascular health to aortic stenosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf491","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T11:57:29Z","timestamp":1754049449000},"page":"1728-1737","source":"Crossref","is-referenced-by-count":5,"title":["Aortic stenosis risk and Life\u2019s Crucial 9: the role of proteomics and inflammation"],"prefix":"10.1093","volume":"32","author":[{"given":"Hao","family":"Xiang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-7982","authenticated-orcid":false,"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"National Clinical Research Center for Kidney Disease , Guangzhou 510515 ,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Institute of Nephrology , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"2025120401164532900_zwaf491-B1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global epidemiology of valvular heart disease","volume":"18","author":"Coffey","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2025120401164532900_zwaf491-B2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jacc.2024.11.051","article-title":"Transcatheter aortic valve replacement beyond severe aortic stenosis: JACC state-of-the-art review","volume":"85","author":"Beerkens","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"2025120401164532900_zwaf491-B3","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2025120401164532900_zwaf491-B4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association\u2019s strategic impact goal through 2020 and beyond","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"2025120401164532900_zwaf491-B5","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1161\/CIR.0000000000001078","article-title":"Life\u2019s Essential 8: updating and enhancing the American Heart Association\u2019s construct of cardiovascular health: a presidential advisory from the American Heart Association","volume":"146","author":"Lloyd-Jones","year":"2022","journal-title":"Circulation"},{"key":"2025120401164532900_zwaf491-B6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/CIRCULATIONAHA.123.066132","article-title":"Strengthening the pillars of cardiovascular health: psychological health is a crucial component","volume":"149","author":"Gaffey","year":"2024","journal-title":"Circulation"},{"key":"2025120401164532900_zwaf491-B7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijcard.2018.07.107","article-title":"Life\u2019s simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women","volume":"269","author":"Perrot","year":"2018","journal-title":"Int J Cardiol"},{"key":"2025120401164532900_zwaf491-B8","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41591-019-0665-2","article-title":"Plasma protein patterns as comprehensive indicators of health","volume":"25","author":"Williams","year":"2019","journal-title":"Nat Med"},{"key":"2025120401164532900_zwaf491-B9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1126\/science.aaq1327","article-title":"Co-regulatory networks of human serum proteins link genetics to disease","volume":"361","author":"Emilsson","year":"2018","journal-title":"Science"},{"key":"2025120401164532900_zwaf491-B10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jacc.2023.11.021","article-title":"Large-scale proteomics identifies novel biomarkers and circulating risk factors for aortic stenosis","volume":"83","author":"Shelbaya","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2025120401164532900_zwaf491-B11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3390\/nu15030781","article-title":"Proteomic mediators of overall cardiovascular health on all-cause mortality","volume":"15","author":"Tanaka","year":"2023","journal-title":"Nutrients"},{"key":"2025120401164532900_zwaf491-B12","doi-asserted-by":"crossref","first-page":"15024","DOI":"10.1038\/s41598-024-65977-3","article-title":"Life\u2019s Essential 8 is inversely associated with high-sensitivity C-reactive protein","volume":"14","author":"Hebib","year":"2024","journal-title":"Sci Rep"},{"key":"2025120401164532900_zwaf491-B13","doi-asserted-by":"crossref","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"2025120401164532900_zwaf491-B14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jamacardio.2018.1717","article-title":"Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK Biobank study","volume":"3","author":"Said","year":"2018","journal-title":"JAMA Cardiol"},{"key":"2025120401164532900_zwaf491-B15","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ajcnut.2023.08.007","article-title":"Adherence to Life\u2019s Essential 8 and incident chronic kidney disease: a prospective study of 147,988 UK Biobank participants","volume":"118","author":"Tang","year":"2023","journal-title":"Am J Clin Nutr"},{"key":"2025120401164532900_zwaf491-B16","first-page":"613","article-title":"An ultra-brief screening scale for anxiety and depression: the PHQ-4","volume":"50","author":"Kroenke","year":"2009","journal-title":"Psychosomatics"},{"key":"2025120401164532900_zwaf491-B17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"2025120401164532900_zwaf491-B18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1001\/jamainternmed.2023.0015","article-title":"Association of cardiovascular health with life expectancy free of cardiovascular disease, diabetes, cancer, and dementia in UK adults","volume":"183","author":"Wang","year":"2023","journal-title":"JAMA Intern Med"},{"key":"2025120401164532900_zwaf491-B19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/eurheartj\/ehae406","article-title":"Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis","volume":"46","author":"Li","year":"2025","journal-title":"Eur Heart J"},{"key":"2025120401164532900_zwaf491-B20","first-page":"1684","article-title":"Cardiovascular risk factors and aortic valve stenosis: towards 10-year absolute risk charts for primary prevention","volume":"32","author":"Kjeldsen","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"2025120401164532900_zwaf491-B21","first-page":"1793","article-title":"Development and validation of the Aortic valve Stenosis Guarded by Amplified Risk Determination (ASGARD) risk score for safe monitoring in asymptomatic non-severe aortic valve stenosis","volume":"32","author":"Hadziselimovic","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"2025120401164532900_zwaf491-B22","doi-asserted-by":"crossref","first-page":"100958","DOI":"10.1016\/j.ajpc.2025.100958","article-title":"Sleep disorders as risk factors for calcific aortic stenosis","volume":"22","author":"El Jamal","year":"2025","journal-title":"Am J Prev Cardiol"},{"key":"2025120401164532900_zwaf491-B23","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.jacc.2019.01.041","article-title":"Screening and management of depression in patients with cardiovascular disease: JACC state-of-the-art review","volume":"73","author":"Jha","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025120401164532900_zwaf491-B24","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1093\/eurheartj\/ehad170","article-title":"Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation","volume":"44","author":"Valenzuela","year":"2023","journal-title":"Eur Heart J"},{"key":"2025120401164532900_zwaf491-B25","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/eurjpc\/zwad177","article-title":"Lifestyle patterns, genetic susceptibility, and risk of valvular heart disease: a prospective cohort study based on the UK Biobank","volume":"30","author":"Jia","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"2025120401164532900_zwaf491-B26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jcin.2024.11.036","article-title":"Effect of sodium-glucose cotransporter-2 inhibitors on the progression of aortic stenosis","volume":"18","author":"Shah","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"2025120401164532900_zwaf491-B27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ejhf.3145","article-title":"Myocardial sodium-glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: the BIO-AS study","volume":"26","author":"Scisciola","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"2025120401164532900_zwaf491-B28","first-page":"133","article-title":"Endothelial dysfunction in metabolic syndrome","volume":"47","author":"Cozma","year":"2009","journal-title":"Rom J Intern Med"},{"key":"2025120401164532900_zwaf491-B29","first-page":"96","article-title":"Inflammatory features of obesity and smoke exposure and the immunologic effects of exercise","volume":"25","author":"Batatinha","year":"2019","journal-title":"Exerc Immunol Rev"},{"key":"2025120401164532900_zwaf491-B30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12967-022-03363-1","article-title":"The role of neutrophil elastase in aortic valve calcification","volume":"20","author":"Liu","year":"2022","journal-title":"J Transl Med"},{"key":"2025120401164532900_zwaf491-B31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s10020-022-00433-4","article-title":"Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity","volume":"28","author":"Zhang","year":"2022","journal-title":"Mol Med"},{"key":"2025120401164532900_zwaf491-B32","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0735-1097(01)01484-X","article-title":"C-reactive protein is increased in patients with degenerative aortic valvular stenosis","volume":"38","author":"Galante","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2025120401164532900_zwaf491-B33","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.bbi.2024.05.005","article-title":"Plasma proteomic biomarkers and the association between poor cardiovascular health and incident dementia: the UK Biobank study","volume":"119","author":"Beydoun","year":"2024","journal-title":"Brain Behav Immun"},{"key":"2025120401164532900_zwaf491-B34","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.123.321673","article-title":"Clinical potential of adrenomedullin signaling in the cardiovascular system","volume":"132","author":"B\u00e1lint","year":"2023","journal-title":"Circ Res"},{"key":"2025120401164532900_zwaf491-B35","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1136\/heartjnl-2021-320707","article-title":"Novel predictive role for mid-regional proadrenomedullin in moderate to severe aortic stenosis","volume":"108","author":"Tan","year":"2022","journal-title":"Heart"},{"key":"2025120401164532900_zwaf491-B36","doi-asserted-by":"crossref","first-page":"8439","DOI":"10.3390\/ijms23158439","article-title":"Targeting fatty acid-binding protein 4 improves pathologic features of aortic stenosis","volume":"23","author":"Garaikoetxea","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025120401164532900_zwaf491-B37","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.atherosclerosis.2011.08.033","article-title":"HGF\/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro","volume":"219","author":"Liu","year":"2011","journal-title":"Atherosclerosis"},{"key":"2025120401164532900_zwaf491-B38","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1159\/000458737","article-title":"Kidney injury molecule-1 is elevated in nephropathy and mediates macrophage activation via the Mapk signalling pathway","volume":"41","author":"Tian","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2025120401164532900_zwaf491-B39","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.7150\/thno.109182","article-title":"AMBP protects against aortic valve calcification by inhibiting ERK1\/2 and JNK pathways mediated by FHL3","volume":"15","author":"Guo","year":"2025","journal-title":"Theranostics"},{"key":"2025120401164532900_zwaf491-B40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10408363.2019.1615034","article-title":"Growth differentiation factor 15: a novel biomarker with high clinical potential","volume":"56","author":"Desmedt","year":"2019","journal-title":"Crit Rev Clin Lab Sci"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article-pdf\/doi\/10.1093\/eurjpc\/zwaf491\/63927783\/zwaf491.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/32\/17\/1728\/63927783\/zwaf491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/32\/17\/1728\/63927783\/zwaf491.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:16:56Z","timestamp":1764829016000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/32\/17\/1728\/8221765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":40,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,8,4]]},"published-print":{"date-parts":[[2025,12,4]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwaf491","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,8,4]]}}}