{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:19:04Z","timestamp":1793319544412,"version":"4.5.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interdisciplinary Centre fo Mathematical and Computational Modelling"},{"DOI":"10.13039\/501100006445","name":"University of Warsaw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is one of the most common inflammatory diseases worldwide, affecting over half of the population. It is a focus of chronic low-grade systemic inflammation, which is thought to contribute to the pathogenesis of cardiovascular diseases, including atrial fibrillation (AF), the most common supra-ventricular arrhythmia. A review of available epidemiological and pathophysiological studies, despite existing methodological limitations, indicates that individuals with moderate to severe periodontitis have a significantly higher risk of developing AF, and in patients already suffering from AF, the presence of periodontitis is associated with a poorer prognosis: a higher risk of recurrent arrhythmia, stroke, and cardiovascular events. Multiple mechanisms linking both diseases have been identified, including chronic immune activation, pro-inflammatory cytokines (CRP, IL-6, and TNF-\u03b1), autoimmunity, atrial fibrosis, and the direct effects of oral pathogens (e.g. Porphyromonas gingivalis) on myocardial tissue. Furthermore, these diseases share many risk factors: obesity, diabetes, smoking, and low socioeconomic status. Scientific evidence indicates that periodontal treatment (scaling, periodontal therapy, improved oral hygiene) significantly reduces inflammatory markers and the risk of AF. The authors propose that oral health be considered as part of integrated care for patients with AF (ABC pathway). Despite the growing body of evidence, current cardiology guidelines do not address the role of periodontitis, indicating the need for updated standards of care. This narrative review summarizes the current knowledge regarding the relationship between periodontitis and AF.<\/jats:p>","DOI":"10.1093\/eurjpc\/zwaf626","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:43:25Z","timestamp":1759837405000},"source":"Crossref","is-referenced-by-count":12,"title":["Periodontitis and atrial fibrillation"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-6664","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"Surma","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia , Katowice 40-752 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , Liverpool L14-3PE ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg 9220 ,","place":["Denmark"]},{"name":"Department of Cardiology, Lipidology and Internal Medicine with Intensive Coronary Care Unit, Medical University of Bialystok , Bialystok 15-540 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"2025102110022511800_zwaf626-B1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3390\/ijerph22040624","article-title":"The global burden of periodontal disease: a narrative review on unveiling socioeconomic and health challenges","volume":"22","author":"Hashim","year":"2025","journal-title":"Int J Environ Res Public Health"},{"key":"2025102110022511800_zwaf626-B2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11906-021-01140-x","article-title":"Periodontitis, blood pressure, and the risk and control of arterial hypertension: epidemiological, clinical, and pathophysiological aspects\u2014review of the literature and clinical trials","volume":"23","author":"Surma","year":"2021","journal-title":"Curr Hypertens Rep"},{"key":"2025102110022511800_zwaf626-B3","first-page":"272","article-title":"Unexpected relationships: periodontal diseases: atherosclerosis-plaque destabilization? 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