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This second part is focused on evidence exploring the effect of different therapies, from lipid-lowering to anti-inflammatory drugs, on atherosclerosis progression. Although statins\u2014particularly at higher doses\u2014have the most extensive data supporting their effect on atherosclerosis, mainly resulting in fibro-lipidic plaque volume regression, emerging data suggest that non-statin lipid-lowering drugs and anti-inflammatory therapies may also affect the natural history of atherosclerosis. However, it should be noted that the absolute change in coronary plaque volume is generally limited, underscoring the need for further research on pharmacological intervention targeting atherosclerosis for early identification and treatment of patients at higher risk.<\/jats:p>","DOI":"10.1093\/eurjpc\/zwaf654","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T02:32:56Z","timestamp":1762655576000},"source":"Crossref","is-referenced-by-count":5,"title":["Therapies leading to coronary atherosclerosis plaque regression: a scientific statement of the European Association of Preventive Cardiology, the European Association of Cardiovascular Imaging of the ESC, the ESC Working Group on Atherosclerosis and Vascular Biology, and the ESC Working Group on Cardiovascular Pharmacotherapy Part 2\u2014drugs\u2019 specific effect on atherosclerosis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-5788","authenticated-orcid":false,"given":"Edoardo","family":"Conte","sequence":"first","affiliation":[{"name":"Clinical Cardiology and Cardiovascular Imaging Unit, Galeazzi-Sant\u2019Ambrogio Hospital IRCCS , via Cristina Belgioioso 173, Milan 20100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-7908","authenticated-orcid":false,"given":"Francesco","family":"Perone","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Unit, Rehabilitation Clinic \u2018Villa Delle Magnolie\u2019 , 81020, Castel Morrone, Caserta ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cosyns","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel , Brussel ,","place":["Belgium"]},{"name":"Centrum Voor Hart-en Vaatziekten, Universitair Ziekenhuis Brussel , Jette ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R","family":"Dweck","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science, The University of Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-3389","authenticated-orcid":false,"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Rennes, CHU Rennes, INSERM , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-0181","authenticated-orcid":false,"given":"Isabel","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Translational Studies, Clinical Sciences Malm\u00f6 Lund University Sweden , Malmo ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-254X","authenticated-orcid":false,"given":"Borja","family":"Ibanez","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation, Centro Nacional de Investigaciones Cardiovasculares (CNIC) & IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, UAM & CIBERCV , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Kaski","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Cell Sciences Research, St. George\u2019s University Hospitals NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Maurovich-Horvat","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Imaging Center, Semmelweis University , Budapest 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