{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:45:47Z","timestamp":1785361547039,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL071981"],"award-info":[{"award-number":["HL071981"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL034594"],"award-info":[{"award-number":["HL034594"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL126024"],"award-info":[{"award-number":["HL126024"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK115679"],"award-info":[{"award-number":["DK115679"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK091718"],"award-info":[{"award-number":["DK091718"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK100383"],"award-info":[{"award-number":["DK100383"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK078616"],"award-info":[{"award-number":["DK078616"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Blood proteomic profiling may model vascular biological ageing with high precision. This study aimed to assess the association between blood pressure and proteomic vascular ageing, and its potential mediation role in the relationship between high blood pressure and incident cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Among 45 387 UK Biobank participants, we developed a proteomic vascular ageing signature (vascular age gap) using 21 heart- and artery-enriched proteins via a LightGBM model. Associations with vascular age gap were evaluated for blood pressure categories and continuous systolic\/diastolic blood pressure (SBP\/DBP). Mediation analyses examined the role of proteomic vascular ageing in the link between high blood pressure and cardiovascular events. Compared to normotensive participants, the vascular age gap was significantly higher in those with high-normal blood pressure (0.122 \u00b1 0.048 years, P = 0.011), Grade 1 hypertension (0.266 \u00b1 0.049 years, P &amp;lt; 0.001), and Grade 2 hypertension (0.494 \u00b1 0.071 years, P &amp;lt; 0.001). Non-linear associations were observed for both SBP and DBP, with thresholds near 120\/80\u2005mmHg. The associations were stronger in midlife adults. The vascular age gap may mediate 3.73\u201310.59% of the association between Grade 2 hypertension and cardiovascular events. No mediation was observed for peripheral artery disease in Grade 2 hypertension. The most influential proteins exhibited potential mediation effects, with TNFRSF11B and CRLF1 consistently contributing to mediation across blood pressure categories and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High blood pressure is associated with accelerated proteomic vascular ageing, which potentially mediates its link to cardiovascular events. This supports vascular age gap as a modest but significant marker of blood pressure-related cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf757","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T12:42:10Z","timestamp":1764506530000},"page":"1103-1112","source":"Crossref","is-referenced-by-count":1,"title":["Blood pressure, proteomic vascular ageing, and incident cardiovascular disease"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-4103","authenticated-orcid":false,"given":"Minghao","family":"Kou","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard , Winston-Salem, NC 27157 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"School of Public Health, Institute of Nutrition, Fudan University , 130 Dong'an Road, Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health , 320 Yueyang Road, Shanghai 200031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Heianza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , 677 Huntington Avenue, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-5633","authenticated-orcid":false,"given":"Kirsten","family":"Dorans","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-1352","authenticated-orcid":false,"given":"Lydia","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6637-6428","authenticated-orcid":false,"given":"Lu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , 677 Huntington Avenue, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"2026051513392864100_zwaf757-B1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High blood pressure and cardiovascular disease","volume":"75","author":"Fuchs","year":"2020","journal-title":"Hypertension"},{"key":"2026051513392864100_zwaf757-B2","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people","volume":"383","author":"Rapsomaniki","year":"2014","journal-title":"Lancet"},{"key":"2026051513392864100_zwaf757-B3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","article-title":"Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis","volume":"387","author":"Ettehad","year":"2016","journal-title":"Lancet"},{"key":"2026051513392864100_zwaf757-B4","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/eurjpc\/zwad028","article-title":"Vascular ageing: moving from bench towards bedside","volume":"30","author":"Climie","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"2026051513392864100_zwaf757-B5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yjmcc.2015.04.011","article-title":"Vascular biology of ageing-implications in hypertension","volume":"83","author":"Harvey","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"2026051513392864100_zwaf757-B6","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.3390\/ijms24086910","article-title":"Aging of the arterial system","volume":"24","author":"Castelli","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026051513392864100_zwaf757-B7","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/HJH.0b013e32834a4d9f","article-title":"Early vascular aging and the role of central blood pressure","volume":"29","author":"Kotsis","year":"2011","journal-title":"J Hypertens"},{"key":"2026051513392864100_zwaf757-B8","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/S0140-6736(16)31134-5","article-title":"A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension","volume":"388","author":"Olsen","year":"2016","journal-title":"Lancet"},{"key":"2026051513392864100_zwaf757-B9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"2026051513392864100_zwaf757-B10","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"2026051513392864100_zwaf757-B11","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/sim.2165","article-title":"Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure","volume":"24","author":"Tobin","year":"2005","journal-title":"Stat Med"},{"key":"2026051513392864100_zwaf757-B12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCULATIONAHA.117.030898","article-title":"Genetic predisposition to high blood pressure and lifestyle factors","volume":"137","author":"Pazoki","year":"2018","journal-title":"Circulation"},{"key":"2026051513392864100_zwaf757-B13","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/HYPERTENSIONAHA.120.15026","article-title":"2020 International Society of Hypertension Global Hypertension practice guidelines","volume":"75","author":"Unger","year":"2020","journal-title":"Hypertension"},{"key":"2026051513392864100_zwaf757-B14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"2026051513392864100_zwaf757-B15","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"GTEx Consortium","year":"2020","journal-title":"Science (New York, NY)"},{"key":"2026051513392864100_zwaf757-B16","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science (New York, NY)"},{"key":"2026051513392864100_zwaf757-B17","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1038\/s41591-024-03164-7","article-title":"Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations","volume":"30","author":"Argentieri","year":"2024","journal-title":"Nat Med"},{"key":"2026051513392864100_zwaf757-B18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s42256-019-0138-9","article-title":"From local explanations to global understanding with explainable AI for trees","volume":"2","author":"Lundberg","year":"2020","journal-title":"Nat Mach Intell"},{"key":"2026051513392864100_zwaf757-B19","author":"Yoshida"},{"key":"2026051513392864100_zwaf757-B20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"2026051513392864100_zwaf757-B21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1126\/science.aaq1327","article-title":"Co-regulatory networks of human serum proteins link genetics to disease","volume":"361","author":"Emilsson","year":"2018","journal-title":"Science (New York, NY)"},{"key":"2026051513392864100_zwaf757-B22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41573-022-00409-3","article-title":"The emerging role of mass spectrometry-based proteomics in drug discovery","volume":"21","author":"Meissner","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"2026051513392864100_zwaf757-B23","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"2026051513392864100_zwaf757-B24","first-page":"e563","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"key":"2026051513392864100_zwaf757-B25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/CIRCULATIONAHA.123.065657","article-title":"Coronary artery calcification: current concepts and clinical implications","volume":"149","author":"Onnis","year":"2024","journal-title":"Circulation"},{"key":"2026051513392864100_zwaf757-B26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.arr.2016.01.007","article-title":"Hypertension and aging","volume":"26","author":"Buford","year":"2016","journal-title":"Ageing Res Rev"},{"key":"2026051513392864100_zwaf757-B27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/HYPERTENSIONAHA.114.03617","article-title":"Aging, arterial stiffness, and hypertension","volume":"65","author":"Sun","year":"2015","journal-title":"Hypertension"},{"key":"2026051513392864100_zwaf757-B28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamainternmed.2017.7023","article-title":"Blood pressure trajectories in the 20 years before death","volume":"178","author":"Delgado","year":"2018","journal-title":"JAMA Intern Med"},{"key":"2026051513392864100_zwaf757-B29","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/HYPERTENSIONAHA.123.22176","article-title":"Association of blood pressure with brain ages: a cohort study of gray and white matter aging discrepancy in mid-to-older adults from UK Biobank","volume":"81","author":"Du","year":"2024","journal-title":"Hypertension"},{"key":"2026051513392864100_zwaf757-B30","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1056\/NEJMoa1901281","article-title":"Final report of a trial of intensive versus standard blood-pressure control","volume":"384","author":"SPRINT Research Group","year":"2021","journal-title":"N Engl J Med"},{"key":"2026051513392864100_zwaf757-B31","doi-asserted-by":"crossref","first-page":"e2037554","DOI":"10.1001\/jamanetworkopen.2020.37554","article-title":"Evaluation of optimal diastolic blood pressure range among adults with treated systolic blood pressure less than 130\u2005mm Hg","volume":"4","author":"Li","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2026051513392864100_zwaf757-B32","doi-asserted-by":"crossref","first-page":"e032771","DOI":"10.1161\/JAHA.123.032771","article-title":"Cardiovascular risk in patients with treated isolated diastolic hypertension and isolated low diastolic blood pressure","volume":"13","author":"Chang","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2026051513392864100_zwaf757-B33","first-page":"CS354233","article-title":"Hypertension prevalence, awareness, treatment, and control among adults age 18 and older: United States, August 2021-August 2023","volume":"511","author":"Fryar","year":"2024","journal-title":"NCHS Data Brief"},{"key":"2026051513392864100_zwaf757-B34","volume-title":"Antihypertensive Medications","author":"Khalil","year":"2023"},{"key":"2026051513392864100_zwaf757-B35","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.jacc.2010.03.013","article-title":"Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity","volume":"55","author":"Venuraju","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2026051513392864100_zwaf757-B36","doi-asserted-by":"crossref","first-page":"e009012","DOI":"10.1161\/JAHA.118.009012","article-title":"Osteoprotegerin and cardiovascular events in high-risk populations: meta-analysis of 19 prospective studies involving 27 450 participants","volume":"7","author":"Tschiderer","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2026051513392864100_zwaf757-B37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/ijms20030705","article-title":"The role of osteoprotegerin and its ligands in vascular function","volume":"20","author":"Rochette","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026051513392864100_zwaf757-B38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pharmthera.2017.08.015","article-title":"The role of osteoprotegerin in the crosstalk between vessels and bone: its potential utility as a marker of cardiometabolic diseases","volume":"182","author":"Rochette","year":"2018","journal-title":"Pharmacol Ther"},{"key":"2026051513392864100_zwaf757-B39","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1038\/s41467-019-13139-9","article-title":"A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension","volume":"10","author":"Arnold","year":"2019","journal-title":"Nat Commun"},{"key":"2026051513392864100_zwaf757-B40","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jacbts.2020.01.016","article-title":"Cardiac fibrosis is associated with decreased circulating levels of full-length CILP in heart failure","volume":"5","author":"Park","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2026051513392864100_zwaf757-B41","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s44161-022-00113-w","article-title":"Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension","volume":"1","author":"Boucherat","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"2026051513392864100_zwaf757-B42","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/ATVBAHA.119.312864","article-title":"Pathologic disparities between peripheral artery disease and coronary artery disease","volume":"40","author":"Narula","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026051513392864100_zwaf757-B43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/1570161115666170227103125","article-title":"Structure of atherosclerotic plaques in different vascular territories: clinical relevance","volume":"16","author":"Poredos","year":"2018","journal-title":"Curr Vasc Pharmacol"},{"key":"2026051513392864100_zwaf757-B44","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.2741\/3440","article-title":"Oxidative stress and accelerated vascular aging: implications for cigarette smoking","volume":"14","author":"Csiszar","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2026051513392864100_zwaf757-B45","doi-asserted-by":"crossref","first-page":"118554","DOI":"10.1016\/j.atherosclerosis.2024.118554","article-title":"Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions","volume":"397","author":"Lan","year":"2024","journal-title":"Atherosclerosis"},{"key":"2026051513392864100_zwaf757-B46","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1152\/japplphysiol.00521.2018","article-title":"Healthy lifestyle-based approaches for successful vascular aging","volume":"125","author":"Rossman","year":"2018","journal-title":"J Appl Physiol (1985)"},{"key":"2026051513392864100_zwaf757-B47","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article-pdf\/doi\/10.1093\/eurjpc\/zwaf757\/65760359\/zwaf757.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/33\/7\/1103\/65760359\/zwaf757.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/33\/7\/1103\/65760359\/zwaf757.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:39:39Z","timestamp":1778866779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/33\/7\/1103\/8369008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,12,5]]},"published-print":{"date-parts":[[2026,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwaf757","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,12,5]]}}}