{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:57:29Z","timestamp":1793059049570,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Bando Salute Regione Toscana 2018","id":[{"id":"https:\/\/ror.org\/02r6c6d62","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NextGeneration EU"},{"name":"PNRR"},{"name":"Progetto Partenariato Esteso 6"},{"name":"HEAL ITALIA","award":["I53C22001440006"],"award-info":[{"award-number":["I53C22001440006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate prevalence, clinical predictors, brain lesions and cognitive test scores of high-risk carotid plaque features\u2014namely intraplaque haemorrhage (IPH), lipid-rich necrotic core (LRNC), and plaque ulceration\u2014in patients with asymptomatic, intermediate-degree carotid artery stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The Carotid Artery Multi-modality imaging Prognostic (CAMP) study is a prospective, observational cohort study enrolling patients with 40\u201360% asymptomatic carotid artery stenosis assessed by Doppler ultrasound. The present study is a cross-sectional analysis of baseline data. High-risk plaque characteristics were evaluated with multimodal vascular imaging, including computed tomography and magnetic resonance angiography, while brain magnetic resonance imaging and neurocognitive testing assessed covert brain infarcts, cerebral small vessel disease, and cognitive functions. Among 155 patients (mean age: 72 years, 27% female, 29% with chronic coronary syndromes), at least one high-risk plaque feature (LRNC, IPH, or ulcer) was present in 51% of cases. IPH and LRNC were present in 23% for both, and ulceration in 38%. Patients with high-risk plaque features had higher high-sensitivity cardiac troponin T and 3-vessel coronary artery disease. Non-lacunar brain infarcts [cortical and large (&amp;gt;15\u2005mm) subcortical brain infarcts] and markers of small vessel disease (lacunar infarcts or white matter hyperintensities) were observed in 11% and 71% of patients, respectively. In univariate analysis, homolateral IPH, LRNC, and \u226550% carotid stenosis were associated with non-lacunar brain infarcts. In multivariable models adjusted for cardiovascular risk factors and carotid stenosis, both IPH and LRNC remained significantly associated with non-lacunar brain infarcts. When high-risk plaque features (LRNC and\/or IPH) and \u226550% stenosis were included in the same model, only high-risk plaque features remained significantly associated with non-lacunar brain infarcts. Low visuospatial and nonverbal memory test scores were common, with a tendency towards poorer performance in patients with high-risk features, although the differences were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High-risk plaque features are frequent in patients with asymptomatic intermediate carotid disease and are associated with non-lacunar covert brain infarcts. Cognitive impairment was common in the cohort, although not associated with high-risk carotid plaque. These findings support the use of a comprehensive plaque characterization beyond stenosis grading for cerebrovascular risk assessment in such patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwaf778","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:44:07Z","timestamp":1769690647000},"source":"Crossref","is-referenced-by-count":5,"title":["High-risk atherosclerotic plaque features, covert brain infarcts, and cognitive performance: a cross-sectional analysis of the carotid artery multi-modality imaging prognostic study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-3271","authenticated-orcid":false,"given":"Gabriele","family":"Masini","sequence":"first","affiliation":[{"name":"University of Pisa and Pisa University Hospital, Cardiology Division , Via Paradisa, Pisa 2- 56124 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