{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:48:58Z","timestamp":1792460938869,"version":"4.5.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic and bariatric surgery (MBS) has long been considered the most effective long-term treatment for severe obesity and its associated comorbidities, including type-2 diabetes mellitus, metabolic syndrome, obstructive sleep apnoea syndrome, and cardiovascular disease. Beyond weight loss, MBS has been associated with improved glycaemic and metabolic control, lower apnoea burden, reduced risk of major adverse cardiovascular events, and improved overall survival. In the last few years, the use of safe and effective weight-loss medications has revolutionized the management of patients with obesity, and may in the future influence referral patterns for MBS. Future research is therefore warranted to clarify the integration between MBS and these novel pharmacological opportunities, with the aim of optimizing patient selection and therapeutic pathways. The aim of this narrative review is therefore to describe the role of MBS in contemporary clinical practice, considering the evolving landscape of pharmacological approaches to treat patients with obesity.<\/jats:p>","DOI":"10.1093\/eurjpc\/zwaf787","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:54:14Z","timestamp":1766580854000},"page":"2627-2638","source":"Crossref","is-referenced-by-count":5,"title":["The evolving role of metabolic and bariatric surgery in contemporary clinical practice"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-5320","authenticated-orcid":false,"given":"Giorgia","family":"Panichella","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-3748","authenticated-orcid":false,"given":"Francesco","family":"Gentile","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0 33, Pisa 56127 ,","place":["Italy"]},{"name":"Cardiology Division, Cardio-Thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. Moruzzi 1, Pisa 56124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Nannipieri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-1962","authenticated-orcid":false,"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0 33, Pisa 56127 ,","place":["Italy"]},{"name":"Cardiology Division, Cardio-Thoracic Department, Fondazione Toscana Gabriele Monasterio , via G. 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