{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:12:32Z","timestamp":1778868752846,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NIH K12 Career Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n Blood pressure (BP) control remains suboptimal among US patients with hypertension. Single-pill combination (SPC) therapies are commonly used to improve adherence; however, their effectiveness for achieving early and sustained intensive BP control is unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n We performed a post hoc analysis of Systolic Blood Pressure Intervention Trial (SPRINT) including 2736 participants propensity matched in a 1:2 ratio to compare effects of SPCs with equivalent multi-pill therapy. The estimated marginal odds of achieving target BP control were derived using generalized linear mixed models with repeated measures (LMMRMs). The association between time-updated SPC use and BP change in short- (\u22646 months) and long-term (&gt;6 months) follow-up was assessed with LMMRM and SPC * time interaction term. Multivariable Cox models evaluated the association of SPC use with cardiovascular events and serious adverse events (SAEs). Among SPRINT participants (n = 8623), 9.3% (n = 803) were prescribed SPC at baseline with greater use in the intensive vs. usual care group (5.79 vs. 3.90 per 100 person-months; P-diff &lt; 0.001). Among matched pairs [SPC (n = 912); multi-pill therapy (n = 1824)], SPC use was associated with 22% increased likelihood of achieving target BP by 6 months [odds ratio (95% confidence interval), 1.22 (1.05, 1.42)]. Participants receiving SPCs (vs. multi-pills) experienced more rapid BP reduction in the first 6 months (\u22122.0 vs. \u22121.2 mmHg monthly change; P-diff &lt; 0.001). Over long-term follow-up, participants using SPCs achieved significantly lower SBP at each time point. The risk of the primary CV composite endpoint and SAEs were not significantly different between groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Single-pill combination use resulted in greater likelihood of achieving target BP control and more rapid, sustained BP reduction without an increase in SAEs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag043","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:30:53Z","timestamp":1768653053000},"page":"1186-1195","source":"Crossref","is-referenced-by-count":0,"title":["Association between single-pill combination therapy use and blood pressure control in the Systolic Blood Pressure Reduction Intervention Trial: a\n post hoc<\/i>\n analysis"],"prefix":"10.1093","volume":"33","author":[{"given":"Shreya","family":"Rao","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, UT Health Sciences Center San Antonio , San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-0897","authenticated-orcid":false,"given":"Matthew W","family":"Segar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Texas Heart Institute , Houston, TX ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-8670","authenticated-orcid":false,"given":"Neil","family":"Keshvani","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Research Institute , Dallas, TX ,","place":["USA"]},{"name":"Baylor The Heart Hospital , Plano, TX ,","place":["USA"]},{"name":"Division of Cardiology, Department of Internal Medicine, UT Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suha","family":"Soni","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, UT Health Sciences Center San Antonio , San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-5601","authenticated-orcid":false,"given":"Anubha","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Medicine and Global Health Center, Washington University in St.Louis , St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D","family":"Huffman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Global Health Center, Washington University in St.Louis , St. Louis, MO, USA"},{"name":"School of Public Health, Washington University in St. Louis , St. Louis, MO, USA"},{"name":"The George Institute for Global Health , Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Hsue","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California , Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-9388","authenticated-orcid":false,"given":"Wanpen","family":"Vongpatanasin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, UT Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasan","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"UT School of Public Health San Antonio, UT Health Sciences Center San Antonio , San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine , Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-3836","authenticated-orcid":false,"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, UT Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"2026051513402876700_zwag043-B1","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Group","year":"2015","journal-title":"N Engl J Med"},{"key":"2026051513402876700_zwag043-B2","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA 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