{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:31:03Z","timestamp":1773325863968,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center"},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea government"},{"DOI":"10.13039\/100019265","name":"Yuhan Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The association between socioeconomic deprivation and atrial fibrillation (AF) remains debated, with limited evidence on its interaction with genetic predisposition. We aimed to evaluate the combined effect of socioeconomic deprivation and genetic risk on incident AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Participants without prior AF from the UK Biobank were included. Socioeconomic deprivation was defined as the top 5% of the Index of Multiple Deprivation (IMD). Genetic risk was assessed using a polygenic risk score (PRS) for AF. The primary outcome was incident AF. Findings were replicated in an independent South Korean cohort. Among 425 423 participants (mean age 56.5 \u00b1 8.1 years; 45.2% male), 21 264 were in the deprived group. The deprived group was younger and had more comorbidities. Atrial fibrillation incidence was higher in the deprived vs. non-deprived group [incidence rate 5.8 vs. 4.7\/1000 person-years; adjusted hazard ratio (aHR) 1.16 (95% confidence interval 1.09\u20131.24), P &amp;lt; 0.001]. Most IMD components (except housing and living environment) were linked to increased AF risk (aHR ranging from 1.13 to 1.19). Deprivation had a stronger effect in those with low genetic risk [lowest PRS tertile: aHR 1.36 (1.19\u20131.56)] compared with those with high genetic risk [highest PRS tertile: aHR 1.11 (1.01\u20131.22); interaction P = 0.0013]. Results were consistent in the Korean cohort (n = 7898).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Socioeconomically deprived individuals have a significantly higher risk of AF, with this risk further influenced by genetic predisposition. Targeted public health policies and personalized AF screening for high-risk groups may help lessen the burden of AF and improve cardiovascular health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag119","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:41:35Z","timestamp":1771591295000},"source":"Crossref","is-referenced-by-count":0,"title":["Combined effect of genetic predisposition and socioeconomic deprivation on atrial fibrillation risk"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-6130","authenticated-orcid":false,"given":"Kyung-Yeon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Korea University Guro Hospital , Seoul, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-0736","authenticated-orcid":false,"given":"Tae-Min","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center , Seoul, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-640X","authenticated-orcid":false,"given":"JungMin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0799-157X","authenticated-orcid":false,"given":"Jae-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4732-637X","authenticated-orcid":false,"given":"Seokmoon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-0378","authenticated-orcid":false,"given":"Hyo-Jeong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-5015","authenticated-orcid":false,"given":"So-Ryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-9615","authenticated-orcid":false,"given":"Seil","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Chest and Heart Hospital , Liverpool ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-6372","authenticated-orcid":false,"given":"Eue-Keun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of \u00a0","place":["Korea"]},{"name":"Department of Internal Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of 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