{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:19:37Z","timestamp":1790363977370,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100031688","name":"Pfizer Pharma GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Concomitant aortic stenosis (AS) and cardiac amyloidosis (CA) result in heart failure and reduced life expectancy. Early detection of CA in AS is an unmet clinical need to prevent disease progression. The SAVER study aims to establish a simple CA screening for AS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>SAVER is a prospective cohort study enrolling AS patients planned for transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). Firstly, patients were assessed for CA-specific symptoms and history on top of AS evaluation. Patients with suspected CA underwent DPD scintigraphy or magnetic resonance imaging. Secondly, we performed multiple-regression analysis to identify optimal parameters for selecting patients at risk of CA. From 2021 to 2023, 1001 patients were enrolled, with 405 (40%) flagged for potential CA. Two hundred six (21%) patients received further diagnostics due to the screening and five (0.5%) patients due to physician discretion, leading to 17 (2%) confirmed CA cases. Key predictors of CA included male sex [OR 23.8 (95% CI 2.6; 216.9)], carpal tunnel syndrome [OR 5.5 (95% CI 1.4; 22.0)], spinal stenosis [OR 4.1 (95% CI 1.1; 14.7)], heaviness or numbness of arms or legs [OR 3.8 (95% CI 1.1; 13.3)], NT-proBNP [OR 6.7 (95% CI 1.8; 25.3)], and sparkling myocardium [OR 4.8 (95% CI 1.3; 17.3)]. The optimized approach reached an AUC of 0.88 (95% CI 0.81\u20130.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SAVER approach is the first holistic screening method focusing on CA\u2019s multiorgan manifestations in AS. This approach can be implemented in clinical settings to prevent futile outcomes of combined disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag158","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:58:03Z","timestamp":1773838683000},"source":"Crossref","is-referenced-by-count":1,"title":["Screening for amyloidosis before aortic valve elective replacement: results from the SAVER study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-3750","authenticated-orcid":false,"given":"Isabel","family":"Mattig","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) , partner site Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Wrede-Wihl","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Augustenburgerplatz 1, Berlin 13353 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin","family":"S\u00f6kmen","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-0761","authenticated-orcid":false,"given":"D\u00f6rte","family":"Huscher","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy , Berlin ,","place":["Germany"]},{"name":"Institute of Biometry and Clinical Epidemiology (IBikE), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wetz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Hindenburgdamm 30, Berlin 12203 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Heidecker","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Hindenburgdamm 30, Berlin 12203 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Hindenburgdamm 30, Berlin 12203 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Barzen","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Pernice","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie und Experimentelle Neurologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Augustenburgerplatz 1, Berlin 13353 ,","place":["Germany"]},{"name":"Structural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Unbehaun","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK) , partner site Berlin ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Augustenburgerplatz 1, Berlin 13353 ,","place":["Germany"]},{"name":"Structural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiothoracic and Vascular Surgery , Augustenburger Platz 1, Berlin 13353 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sherif","sequence":"additional","affiliation":[{"name":"SEHA Sh. Tahnoon Bin Medical City , Abu Dhabi ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-0347","authenticated-orcid":false,"given":"Anna","family":"Brand","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) , partner site Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Leistner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 3 - Kardiologie, Angiologie, Universit\u00e4tsklinikum Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Rhine\/Main , Frankfurt am Main 60590 ,","place":["Deutschland"]},{"name":"Cardiopulmonary Institute (CPI) , Frankfurt am Main 60590 ,","place":["Deutschland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Spethmann","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-0773","authenticated-orcid":false,"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, Berlin 10117 ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) , partner site Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk","family":"Dreger","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK) , partner site Berlin ,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Department of Cardiology, Angiology and Intensive Care Medicine , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Augustenburgerplatz 1, Berlin 13353 ,","place":["Germany"]},{"name":"Structural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charit\u00e9 , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hahn","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Klinik f\u00fcr Neurologie und Experimentelle Neurologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Knebel","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK) , partner site Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy , Berlin ,","place":["Germany"]},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Sana Klinikum Lichtenberg, Innere Medizin II: Schwerpunkt Kardiologie , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Messroghli","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), 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