{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:23:10Z","timestamp":1780597390771,"version":"3.54.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23CDA1050962"],"award-info":[{"award-number":["23CDA1050962"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The American Heart Association\u2019s Life\u2019s Essential 8 cardiovascular health (CVH) construct strongly predicts cardiovascular disease (CVD), yet biological processes associated with early-life CVH trajectories are unclear. We examined associations of CVH score and trajectory parameters across childhood with cardiovascular-related proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We derived CVH scores (0\u2013100 points) in 424 children at median ages 3.2, 7.7, 13, and 17.5y. Segmented mixed-effect models estimated three CVH trajectory parameters: timing of inflection when CVH declines and slope before and after inflection. We assayed 92 proteins from plasma samples in late adolescence (17.5y). Linear regression models assessed cross-sectional (CVH in late adolescence) and longitudinal (CVH trajectory parameters) associations with proteins, with false discovery rate correction via Benjamini\u2013Hochberg method. Mean (SD) late-adolescent CVH was 75.5 (10.5) points. Cardiovascular health slope before inflection was 0.6 (1.4) points\/y, timing of inflection was 10.1y (0.7), and slope after inflection was \u22121.2 (1.2) points\/y. Cross-sectionally, a 1-SD higher CVH was associated with 29 differentially abundant proteins (DAPs); five showed robust associations with log2\u2013fold change \u2265|0.2| (higher FGF-21, HAOX1, IL-1ra, LEP, and lower GH). Longitudinally, 1-SD increments in CVH trajectory parameters were associated with up to 13 DAPs; specifically, we observed robust associations of timing of CVH inflection with higher LEP and CVH slope after inflection with higher IL-1ra, LEP, and SERPINA12. These DAPs implicated lipid metabolism, inflammation, and glyoxylate\/oxalate production pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified novel protein biomarkers reflecting adolescent CVH and cumulative impact of childhood CVH trajectories, which may inform preventive strategies early in life to alter CVD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag176","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:44:38Z","timestamp":1774442678000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular health across childhood and adolescence and proteomic biomarkers in late adolescence"],"prefix":"10.1093","author":[{"given":"Zhi","family":"Lin","sequence":"first","affiliation":[{"name":"Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L","family":"Rifas-Shiman","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , 401 Park Drive, Suite 401E, Boston, MA 401E ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah D","family":"de Ferranti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Perng","sequence":"additional","affiliation":[{"name":"Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]},{"name":"Department of Epidemiology, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , 401 Park Drive, Suite 401E, Boston, MA 401E ,","place":["USA"]},{"name":"Diabetes Unit, Massachusetts General Hospital , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-7476","authenticated-orcid":false,"given":"Izzuddin M","family":"Aris","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , 401 Park Drive, Suite 401E, Boston, MA 401E 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