{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:47:21Z","timestamp":1790084841878,"version":"4.0.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009123","name":"Norwegian University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006397","name":"NTNU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006397","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Association for Heart and Lung Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to present sex-specific reference data for peak oxygen uptake (V\u0307O2peak) in Norwegian patients with coronary artery disease (CAD) undergoing cardiac rehabilitation and examine its association with major adverse cardiovascular events (MACEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively analysed treadmill cardiopulmonary exercise test (CPET) data from 1651 CAD patients (21% women; mean (SD) age 61 (9) years) attending inpatient cardiac rehabilitation (2004\u20132022). Patients were categorized by index event: myocardial infarction (MI), coronary artery bypass grafting (CABG), or percutaneous coronary intervention\/pharmacologically treated CAD (PCI\/CAD). Age-, sex-, and diagnosis-specific V\u0307O2peak reference data were generated. Associations between V\u0307O2peak and a combined MACE endpoint (all-cause mortality, acute coronary syndrome, stroke, or heart failure) were assessed using Cox proportional hazards models, including natural cubic splines for assessing non-linear patterns. Men had higher V\u0307O2peak than women (26.9 (6.7) vs. 23.2 (5.3) mL\u00b7kg\u22121\u00b7min\u22121; P &amp;lt; 0.001). V\u0307O2peak was on average 2.5 and 1.7 mL\u00b7kg\u22121\u00b7min\u22121 lower per decade of age in men and women, respectively. Patients with a previous MI had the highest V\u0307O2peak, followed by CABG and PCI\/CAD (P &amp;lt; 0.001). During 7880 person-years, 510 patients (36%) experienced MACE. Each 1 mL\u00b7kg\u22121\u00b7min\u22121 higher V\u0307O2peak was associated with a 7% lower MACE risk (HR [95% CI]; 0.93 [0.92\u20130.95]) in men and 5% (HR [95% CI]; 0.95 [0.91\u20130.99]) in women. Patients in the highest cardiorespiratory fitness quartile had a 55% lower risk compared to the lowest quartile. Associations were consistent across CAD subcategories. Sex-specific natural cubic spline models revealed inverse, non-linear associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides novel sex- and diagnosis-specific V\u0307O2peak reference values for Norwegian CAD patients and confirms V\u0307O2peak as a strong prognostic marker, supporting its integration into routine secondary prevention and individualized care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag194","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:35:44Z","timestamp":1775561744000},"page":"2467-2476","source":"Crossref","is-referenced-by-count":1,"title":["Sex-specific V\u0307O2peak reference values and their association with major adverse cardiovascular events in Norwegian cardiac rehabilitation patients"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2331-8470","authenticated-orcid":false,"given":"Alexander","family":"Svenningsen","sequence":"first","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology , Postboks 8905, Trondheim 7491 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-3745","authenticated-orcid":false,"given":"Siri Marte","family":"Hollekim-Strand","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-4338","authenticated-orcid":false,"given":"Jon Arne","family":"Sandm\u00e6l","sequence":"additional","affiliation":[{"name":"Unicare R\u00f8ros, Unicare Rehabilitation , R\u00f8ros ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-460X","authenticated-orcid":false,"given":"Harald","family":"Engan","sequence":"additional","affiliation":[{"name":"Unicare Trondheim, Unicare Rehabilitation , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-3587","authenticated-orcid":false,"given":"Ulrik","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology , Postboks 8905, Trondheim 7491 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-9904","authenticated-orcid":false,"given":"Jon Magne","family":"Letnes","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology , Postboks 8905, Trondheim 7491 ,","place":["Norway"]},{"name":"Clinic of Cardiology, St.Olav University Hospital , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"2026092119572308000_zwag194-B1","doi-asserted-by":"crossref","first-page":"e022198","DOI":"10.1161\/JAHA.121.022198","article-title":"Event rates and risk factors for recurrent cardiovascular events and mortality in a contemporary post acute coronary syndrome population representing 239 234 patients during 2005 to 2018 in the United States","volume":"11","author":"Steen","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2026092119572308000_zwag194-B2","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice: developed by the task force for cardiovascular disease 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