{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:22:31Z","timestamp":1782451351927,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["#326461"],"award-info":[{"award-number":["#326461"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with acute increases in cardiac troponin and a higher risk of cardiovascular outcomes, but the interaction between SARS-CoV-2 and chronic subclinical myocardial injury is unclear. Accordingly, we aimed to assess the associations between SARS-CoV-2 infection and chronic subclinical myocardial injury in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured cardiac troponin I (cTnI) with a high-sensitivity assay in 37 823 persons recruited from the general population participating in the Tr\u00f8ndelag Health Study immediately before (2018 to 2019, pre-pandemic) the COVID-19 pandemic. Of these, the measurement of cTnI and SARS-CoV-2-spike IgG and nucleocapsid IgG was performed in 19 550 persons after (2021\u20132023, post-pandemic) the COVID-19 pandemic. We assessed the associations of immunological, self-reported, and laboratory-verified SARS-CoV-2 infection with changes in cTnI from pre- to post-pandemic, as well as the association of pre-pandemic cTnI with the risk of incident SARS-CoV-2 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher pre-pandemic cTnI was associated with a lower risk of contracting SARS-CoV-2. Interim SARS-CoV-2 infection was associated with higher concentrations of post-pandemic cTnI and a higher probability of increasing pre- to post-pandemic concentration of cTnI when adjusting for potential confounders and pre-pandemic cTnI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a large cohort of community dwellers, SARS-CoV-2 is associated with a higher probability of increasing concentrations of cTnI from before to after infection, reinforcing the role of SARS-CoV-2 infection in the development of chronic subclinical myocardial injury. In contrast, pre-existing chronic subclinical myocardial injury was not associated with increased risk of contracting SARS-CoV-2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag228","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:40:56Z","timestamp":1779363656000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Tr\u00f8ndelag Health Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-0369","authenticated-orcid":false,"given":"Torbj\u00f8rn","family":"Omland","sequence":"first","affiliation":[{"name":"Department of Cardiology, Division of Medicine, Akershus University Hospital , PO Box 1000, L\u00f8renskog NO-1478 ,","place":["Norway"]},{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , PO Box 1072, Blindern, Oslo NO-0316 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-9744","authenticated-orcid":false,"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology , Levanger ,","place":["Norway"]},{"name":"Levanger Hospital, Nord-Tr\u00f8ndelag Hospital Trust , Levanger ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Varounis","sequence":"additional","affiliation":[{"name":"Abbott Diagnostics , Abbott Park, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5994-9304","authenticated-orcid":false,"given":"Magnus Nakrem","family":"Lyngbakken","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Medicine, Akershus University Hospital , PO Box 1000, L\u00f8renskog NO-1478 ,","place":["Norway"]},{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , PO Box 1072, Blindern, Oslo NO-0316 ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026052611554780400_zwag228-B1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-044640","article-title":"Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies","volume":"11","author":"Pijls","year":"2021","journal-title":"BMJ Open"},{"key":"2026052611554780400_zwag228-B2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12016-022-08921-5","article-title":"Risk and protective factors for COVID-19 morbidity, severity, and mortality","volume":"64","author":"Zhang","year":"2023","journal-title":"Clin Rev Allergy 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