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Epidemiological studies on the associations of daytime and night-time light exposures with cardiovascular disease (CVD) risk are limited and have examined these exposures separately, yielding contradictory findings. We aimed to examine the association between the distinction between daytime and night-time light exposure and CVD mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This population-based retrospective cohort study included 7607 adults from the US National Health and Nutrition Examination Survey (2011\u201314) who wore an accelerometer with a light sensor for a week. Cardiovascular disease mortality data were obtained through linkage to the National Death Index until 2019. We estimated differences in time between daytime light exposure above 1000 lux vs. night-time light exposure above 1 lux. We used Cox models to estimate hazard ratios (HRs) for CVD mortality, adjusting for physical activity, sleep duration, chronotype, serum 25-hydroxyvitamin D, and other covariates. The study population (46.8% male, 67.9% non-Hispanic white) had a baseline mean age of 49.4 years (SE, 0.4). Over a median follow-up of 6.8 years, 233 CVD deaths occurred. Greater differences in daytime vs. night-time light exposure were associated with a lower CVD mortality risk in a linear dose\u2013response pattern [per 1 h increment: HR, 0.88 (95% confidence interval, 0.78\u20130.98); Pnon-linearity = 0.92]. The association showed no evidence of heterogeneity by age or sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater distinctions between daytime and night-time light exposure were associated with lower CVD mortality among US adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag303","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:46:18Z","timestamp":1780487178000},"source":"Crossref","is-referenced-by-count":2,"title":["Objectively measured individual-level daytime vs. night-time light exposure and cardiovascular disease mortality in US adults"],"prefix":"10.1093","author":[{"given":"Jin","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"Bureau of Family Health, Louisiana Department of Health , 1450 Poydras Street, New Orleans, LA 70112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-710X","authenticated-orcid":false,"given":"Xiaoyu","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine , St. Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Heianza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn E","family":"Manson","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , 181 Longwood Avenue, Boston, MA 02115 ,","place":["USA"]},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , 677 Huntington Ave, Boston, MA 02115 ,","place":["USA"]},{"name":"Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , 900 Commonwealth Ave, Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6637-6428","authenticated-orcid":false,"given":"Lu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University , 1440 Canal Street, Suite 1724, New Orleans, LA 70112 ,","place":["USA"]},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , 181 Longwood Avenue, Boston, MA 02115 ,","place":["USA"]},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , 677 Huntington Ave, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"2026061613151376800_zwag303-B1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/eurheartj\/ehae001","article-title":"Exposome in ischaemic heart disease: beyond traditional risk factors","volume":"45","author":"Montone","year":"2024","journal-title":"Eur Heart J"},{"key":"2026061613151376800_zwag303-B2","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.1161\/CIR.0000000000001388","article-title":"Role of circadian health in cardiometabolic health and disease risk: a scientific statement from the American Heart Association","volume":"152","author":"Knutson","year":"2025","journal-title":"Circulation"},{"key":"2026061613151376800_zwag303-B3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrn3743","article-title":"Light as a 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