{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:11:02Z","timestamp":1784549462436,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100015722","name":"\u2018Ann\u00e9e Recherche\u2019 of CHU de Clermont-Ferrand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize the cardiovascular magnetic resonance (CMR) phenotype of hypertensive hypertrophic cardiomyopathy (HCM) patients, assess the association between hypertension and all-cause mortality, and compare the long-term prognostic performance of CMR-derived biomarkers between hypertensive and non-hypertensive HCM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Between 2008 and 2024, all consecutive HCM patients referred for CMR from the hypertrophic cardiomyopathy-late gadolinium enhancement registry were included. The primary outcome was all-cause mortality. Clinical variables, cardiac volumes, myocardial mass, functions, and tissue characterization with late gadolinium enhancement (LGE) were assessed in all patients. The prognostic value of hypertension and CMR-derived biomarkers were assessed using survival analysis. Among 2873 patients with HCM (52 \u00b1 8 years, 56% males), 796 (28%) had hypertension. Hypertensive HCM patients had greater LGE extent (1.1 \u00b1 1.8 vs. 0.9 \u00b1 1.5, P &amp;lt; 0.001), more LGE multiple locations (17% vs. 11%, P &amp;lt; 0.001), and more midwall LGE (35% vs. 28%, P = 0.001). After 1:1 propensity score matching, survival curves showed an increased risk of all-cause mortality for hypertensive HCM patients over a median follow-up of 9 years [hazard ratio (HR): 1.32, 95% confidence interval (CI): 1.04\u20131.69; log-rank P = 0.024]. High LGE extent (more than three segments) and septal location of LGE were independently associated with mortality in both hypertensive HCM patients (HR: 3.99, 95% CI: 2.21\u20137.18; P &amp;lt; 0.001 and HR: 1.76, 95% CI: 1.03\u20133.01; P = 0.039, respectively) and non-hypertensive HCM patients (HR: 4.63, 95% CI: 2.15\u20139.97; P &amp;lt; 0.001 and HR: 1.48, 95% CI: 1.02\u20132.15; P = 0.040, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a large multicenter cohort of HCM patients, concomitant hypertension was associated with increased long-term mortality, and prognostic associations of CMR-LGE biomarkers were found. These findings highlight the importance of comprehensive cardiovascular risk assessment in HCM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag343","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:22:55Z","timestamp":1783952575000},"source":"Crossref","is-referenced-by-count":0,"title":["Concomitant hypertension in hypertrophic cardiomyopathy: clinical phenotype and prognostic associations of cardiovascular magnetic resonance biomarkers"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-562X","authenticated-orcid":false,"given":"Jeremy","family":"Florence","sequence":"first","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"Inserm MASCOT\u2013UMRS 942, University Hospital of Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]},{"name":"Cardiology Department, CHU Clermont-Ferrand , Clermont-Ferrand ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-443X","authenticated-orcid":false,"given":"Trecy","family":"Gonc\u0327alves","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"Inserm MASCOT\u2013UMRS 942, University Hospital of Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]},{"name":"Department of Radiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenn","family":"Toupin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"Inserm MASCOT\u2013UMRS 942, University Hospital of Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Garot","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6596-8538","authenticated-orcid":false,"given":"Julien","family":"Hudelo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"Inserm MASCOT\u2013UMRS 942, University Hospital of Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]},{"name":"Department of Cardiology, Amiens University Hospital , Amiens ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sanguineti","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-9185","authenticated-orcid":false,"given":"Thomas","family":"Hovasse","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 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Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Kante","sequence":"additional","affiliation":[{"name":"Inserm MASCOT\u2013UMRS 942, University Hospital of Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Department of Internal Medicine, 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H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-8444","authenticated-orcid":false,"given":"The\u0301o","family":"Pezel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]},{"name":"Inserm MASCOT\u2013UMRS 942, University Hospital of Lariboisi\u00e8re , Paris ,","place":["France"]},{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]},{"name":"Department of Radiology, Universit\u00e9 Paris Cit\u00e9, University Hospital of Lariboisi\u00e8re, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Bohbot","sequence":"additional","affiliation":[{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Department of Cardiology, Amiens University Hospital , Amiens ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3714-1256","authenticated-orcid":false,"given":"Je\u0301ro\u0302me","family":"Garot","sequence":"additional","affiliation":[{"name":"MIRACL.ai Laboratory, Multimodality Imaging for Research and Artificial Intelligence Core Laboratory, University Hospital of Lariboisi\u00e8re (AP-HP) , 2 Rue Amboise Par\u00e9, Paris 75010 ,","place":["France"]},{"name":"Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Ho\u0302pital Prive\u0301 Jacques CARTIER, Ramsay Sante\u0301 , 6 Avenue du Noyer Lambert, Massy 91300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"2026072008004526400_zwag343-B1","first-page":"146","article-title":"Factors influencing the phenotypic expression of hypertrophic cardiomyopathy in genetic carriers","volume":"71","author":"Perez-Sanchez","year":"2018","journal-title":"Rev Esp Cardiol"},{"key":"2026072008004526400_zwag343-B2","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/eurheartj\/ehx527","article-title":"Women with hypertrophic cardiomyopathy have worse survival","volume":"38","author":"Geske","year":"2017","journal-title":"Eur Heart 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