{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:00:20Z","timestamp":1789624820594,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated the risk of MI by RA status and seropositivity and performed exploratory analysis of biologic DMARD (bDMARD) and targeted synthetic DMARD (tsDMARD) use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This retrospective cohort study used the Korean National Health Insurance System database. Patients aged \u2265 40 years newly diagnosed with RA (n\u2009=\u200936,377) were matched 1:3 with non-RA controls (n\u2009=\u2009109,131). Fine and Gray subdistribution hazard models estimated subdistribution hazard ratios (sHR) for MI risk by RA status, seropositivity, bDMARD, and tsDMARD use. During a mean follow-up of 5.6\u2009\u00b1\u20092.3 years, 1201 MI events in non-RA, 738 in RA, 186 in seronegative RA (SNRA), 552 in seropositive RA (SPRA), 64 with bDMARD use, and 4 with tsDMARD use were identified. Patients with RA had a 1.8-fold increased MI risk compared to non-RA (sHR: 1.84, 95% CI: 1.67\u20132.01). SNRA and SPRA showed similar risks (sHR: 1.74, 95% CI: 1.49\u20132.04, and sHR: 1.87, 95% CI: 1.69\u20132.07, respectively). MI risk remained elevated both with and without bDMARD use (sHR: 2.34, 95% CI: 2.05\u20132.67; sHR: 1.81, 95% CI: 1.72\u20131.91, respectively). Non-use of tsDMARDs was associated with increased MI risk (sHR: 1.86, 95% CI: 1.77\u20131.96), whereas tsDMARD use was not significantly associated with MI (sHR: 1.43, 95% CI: 0.90\u20132.28).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RA was associated with increased MI risk irrespective of seropositivity status. Exploratory analyses suggested that tsDMARD users did not exhibit increased MI risk, although the small number of events warrants large-scale prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag358","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:53:50Z","timestamp":1783598030000},"source":"Crossref","is-referenced-by-count":1,"title":["Rheumatoid arthritis and risk of myocardial infarction: A nationwide cohort study"],"prefix":"10.1093","author":[{"given":"In Young","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Family Medicine\/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine , Suwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonyoung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-6112","authenticated-orcid":false,"given":"Seonghye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine\/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonyoung","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6155-1389","authenticated-orcid":false,"given":"Alicia","family":"Shin","sequence":"additional","affiliation":[{"name":"University of California , Los Angeles ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Medical Humanities, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-1263","authenticated-orcid":false,"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-8920","authenticated-orcid":false,"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine\/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University , Seoul ,","place":["Republic of Korea"]},{"name":"Department of Digital Health, Samsung Advanced Institute of Health Science and Technology (SAIHST), Sungkyunkwan University , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,10]]},"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article-pdf\/doi\/10.1093\/eurjpc\/zwag358\/68755088\/zwag358.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article-pdf\/doi\/10.1093\/eurjpc\/zwag358\/68755088\/zwag358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:19:54Z","timestamp":1783693194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article\/doi\/10.1093\/eurjpc\/zwag358\/8731992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwag358","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"article-number":"zwag358"}}