{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:42:04Z","timestamp":1788432124949,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370381"],"award-info":[{"award-number":["82370381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Clinical Medical Technology Innovation Leadership Project","award":["2021SK53512"],"award-info":[{"award-number":["2021SK53512"]}]},{"name":"Yu-Ying Plan of the Central South University","award":["502034007"],"award-info":[{"award-number":["502034007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Systemic inflammation has been implicated in valvular degeneration, but prospective evidence across major non-rheumatic valvular phenotypes remains limited. We investigated the associations of circulating inflammatory indicators with incident valvular heart disease in the UK Biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This prospective cohort study included 250 532 participants free of cardiovascular disease, valvular heart disease, and autoimmune disease at baseline. Baseline systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio, neutrophil-to-platelet ratio (NPR), lymphocyte-to-monocyte ratio (LMR), and C-reactive protein were assessed. Multivariable Cox proportional hazards models were used to examine associations with clinically diagnosed incident aortic stenosis (AS), mitral regurgitation (MR), aortic regurgitation (AR), and valve-related events. Restricted cubic spline analyses, subgroup analyses, and sensitivity analyses were performed. Over a median follow-up of 13.22\u2005years, incident AS occurred in 1904 participants, incident MR in 2140, and incident AR in 757; 1369 valve-related events were also recorded. Higher SIRI was associated with increased risks of AS [hazard ratio (HR) per 1-standard deviation, 1.07; 95% confidence interval (CI), 1.03\u20131.11], MR (HR, 1.10; 95% CI, 1.05\u20131.14), and valve-related events (HR, 1.08; 95% CI, 1.03\u20131.13). Higher LMR was associated with lower risks of AS (HR, 0.91; 95% CI, 0.86\u20130.96), MR (HR, 0.93; 95% CI, 0.89\u20130.98), and valve-related events (HR, 0.88; 95% CI, 0.82\u20130.94). NPR was positively associated with MR and valve-related events, whereas no indicators showed a clear association with AR after full adjustment. These patterns were broadly consistent across dose\u2013response, subgroup, and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic inflammatory indices, particularly SIRI and LMR, were independently associated with incident AS, MR, and valve-related events, whereas no clear association was detected for AR. These findings support a phenotype-specific relationship between systemic inflammation and non-rheumatic valvular heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag362","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:54:42Z","timestamp":1783684482000},"source":"Crossref","is-referenced-by-count":1,"title":["Association of systemic inflammatory indicators with incident valvular heart disease: a prospective analysis of the UK Biobank"],"prefix":"10.1093","author":[{"given":"Yi-Zhou","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University , No. 139 Middle Renmin Road, 410011 Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University , No. 139 Middle Renmin Road, 410011 Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Jiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University , No. 139 Middle Renmin Road, 410011 Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University , No. 139 Middle Renmin Road, 410011 Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Fei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University , No. 139 Middle Renmin Road, 410011 Changsha, Hunan 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