{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:00:40Z","timestamp":1790362840090,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea government"},{"DOI":"10.13039\/501100014188","name":"MSIT","doi-asserted-by":"publisher","award":["2026-25478039"],"award-info":[{"award-number":["2026-25478039"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007687","name":"Korean Diabetes Association","doi-asserted-by":"publisher","award":["2026S-3"],"award-info":[{"award-number":["2026S-3"]}],"id":[{"id":"10.13039\/100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Alcohol use disorder (AUD) is a chronic neuropsychiatric condition associated with clustering cardiovascular risk factors, yet its independent contribution to incident cardiovascular disease in type 2 diabetes (T2D) remains incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using the Korean National Health Insurance Service database, we identified 364 950 adults with T2D (AUD, n = 4888 [1.34%]; non-AUD, n = 360 062 [98.66%]) who underwent national health screening in 2012. Incident major adverse cardiovascular events (MACE), defined as a composite of myocardial infarction, ischaemic stroke, and cardiovascular death, were ascertained over a median follow-up of 10.2 years. Associations were evaluated using multivariable Cox proportional hazards models. AUD was independently associated with a higher risk of incident MACE (hazard ratio [HR] 1.70; 95% confidence interval [CI], 1.59\u20131.82), with the strongest association for cardiovascular death (HR 2.37; 95% CI, 2.06\u20132.72 Among individuals without AUD, a J-shaped association between alcohol consumption and MACE was observed. In contrast, among those with AUD, cardiovascular risk remained elevated across all levels of alcohol intake (all P &amp;lt; 0.001), including among low-risk drinkers (HR 1.44; 95% CI, 1.30\u20131.61). The association was most pronounced in middle-aged adults (40\u201364 years; HR 1.89; 95% CI, 1.75\u20132.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In adults with T2D, AUD was associated with increased risk of incident MACE, even after adjustment for self-reported alcohol consumption volume. These findings suggest that assessment of disordered drinking may complement volume-based alcohol evaluation in cardiovascular risk stratification, although prospective studies are needed to confirm its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag455","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:25:54Z","timestamp":1789673154000},"source":"Crossref","is-referenced-by-count":0,"title":["Alcohol use disorder and cardiovascular risk in type 2 diabetes: beyond alcohol consumption"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-8007","authenticated-orcid":false,"given":"Ji Hye","family":"Heo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hallym University College of Medicine , Hallymdaehak-Gil Chuncheon-si, Gangwon-do, Chuncheon 24252 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung 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Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hallym University College of Medicine , Hallymdaehak-Gil Chuncheon-si, Gangwon-do, Chuncheon 24252 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-7251","authenticated-orcid":false,"given":"Jun Goo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hallym University College of Medicine , Hallymdaehak-Gil Chuncheon-si, Gangwon-do, Chuncheon 24252 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026092514232179900_zwag455-B1","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and 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