{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:48Z","timestamp":1792785888581,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["CFH2024\u20132G-2036"],"award-info":[{"award-number":["CFH2024\u20132G-2036"]}]},{"name":"Beijing Chao-Yang Hospital","id":[{"id":"https:\/\/ror.org\/01eff5662","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["CYFH202310"],"award-info":[{"award-number":["CYFH202310"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20250484858"],"award-info":[{"award-number":["20250484858"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical-Engineering Integration"},{"name":"BRA-CDCHE"},{"name":"ZTA","award":["MBRC0012025021"],"award-info":[{"award-number":["MBRC0012025021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The long-term depressive symptom trajectories across the transition to incident cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational ageing populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this multicohort study, we analysed longitudinal data from the Health and Retirement Study (HRS, 2002\u20132018), English Longitudinal Study of Ageing (ELSA, 2002\u20132019), and China Health and Retirement Longitudinal Study (CHARLS, 2011\u20132018). Depressive symptoms were measured biennially by the 8 item (HRS and ELSA) and 10 item (CHARLS) Center for Epidemiologic Studies Depression Scale and standardized to Z-scores. Incident CVD was ascertained by medical history. Data were analysed using discontinuous growth curve modelling and pooled using meta-analysis. Among 28 704 included participants (mean [SD] age, 62.3 [9.8] years; 43.4% male), 7363 developed CVD during follow-up. Participants who developed CVD had higher depressive symptom scores than those without CVD (pooled \u03b2 [95% confidence interval]: 0.161 SD [0.086\u20130.236]). A significant increase in depressive symptom scores was observed around the time of CVD diagnosis (pooled \u03b2: 0.089 SD [0.060\u20130.118]). Additionally, depressive symptom scores increased both in the years preceding CVD onset (pooled \u03b2: 0.007 SD\/year [0.004\u20130.010]) and following diagnosis (pooled \u03b2: 0.009 SD\/year [0.004\u20130.013]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Depressive symptoms show a gradual increase before CVD diagnosis, elevate further around the time of diagnosis, and continue to worsen thereafter. These findings call for the integration of mental health screening and management into CVD care at all stages, from primary prevention to long-term disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag459","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:14:10Z","timestamp":1788520450000},"source":"Crossref","is-referenced-by-count":0,"title":["Depressive symptom trajectories across the transition to cardiovascular disease in middle-aged and older adults: a multicohort study"],"prefix":"10.1093","author":[{"given":"Jiao","family":"Wang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]},{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , Stockholm 17165 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