{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:48Z","timestamp":1792785888508,"version":"4.5.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI25\/00697"],"award-info":[{"award-number":["PI25\/00697"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00953"],"award-info":[{"award-number":["PI22\/00953"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00443"],"award-info":[{"award-number":["PI19\/00443"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI20\/0080"],"award-info":[{"award-number":["FI20\/0080"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejo Superior de Deportes"},{"name":"Spanish Culture and Sports Ministry","award":["EXP_75119"],"award-info":[{"award-number":["EXP_75119"]}]},{"name":"CONAHCYT","id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"crossref"}]},{"name":"EMERALD","award":["101034290"],"award-info":[{"award-number":["101034290"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate in a rodent model whether the detrimental cardiovascular effects of chronic strenuous exercise observed in males (AF, right ventricular, and vascular maladaptation) also occur in females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Male and female Wistar rats underwent a 16-week high-intensity treadmill regimen or remained sedentary. Structural and functional cardiac parameters were assessed through echocardiography, electrocardiography, invasive haemodynamics, histology, molecular biology, and transcriptomic profiling. Exercise induced comparable physiological left ventricular remodelling in both sexes, alongside systolic and diastolic right ventricular dysfunction. Notably, females developed atrial fibrosis and exhibited a similar propensity for AF as their male counterparts. However, transcriptional remodelling in the atria was sex- and chamber-specific, with exercise-induced gene expression changes being more pronounced in the left atrium of females. In the vasculature, sedentary females displayed superior endothelial function, but unlike males, it failed to improve after training. Furthermore, exercised females developed tunica media fibrosis without accompanying oxidative stress, suggesting divergent mechanisms of vascular injury. Plasma proteomic profiling at rest identified Ccl20 as a candidate biomarker of exercise-induced cardiovascular damage; acute post-exercise responses revealed numerous sex-specific alterations in circulating biomarkers, including those associated with inflammation and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Females engaged in regular strenuous endurance exercise are at an increased risk of AF and vascular harm, similar to males. However, underlying mechanisms and phenotypic expressions are strongly sex-dependent. These findings highlight the importance of incorporating sex-specific approaches into the diagnostic and prognostic evaluation of cardiovascular adaptations and risks associated with endurance training.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag482","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:19:49Z","timestamp":1789672789000},"source":"Crossref","is-referenced-by-count":0,"title":["Strenuous exercise elicits sex-specific cardiovascular maladaptation in a rodent model: atrial fibrillation and vascular risk in females"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-9258","authenticated-orcid":false,"given":"Aline","family":"Meza-Ramos","sequence":"first","affiliation":[{"name":"Medicine and Translational Research Doctorate Programme, Faculty of Medicine, University of Barcelona , Casanova 143, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT) ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-1544","authenticated-orcid":false,"given":"Anna","family":"Alcarraz","sequence":"additional","affiliation":[{"name":"Medicine and Translational Research Doctorate Programme, Faculty of Medicine, University of Barcelona , Casanova 143, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-7839","authenticated-orcid":false,"given":"Cira","family":"Rubies","sequence":"additional","affiliation":[{"name":"Medicine and Translational Research Doctorate Programme, Faculty of Medicine, University of Barcelona , Casanova 143, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-9577","authenticated-orcid":false,"given":"Maria","family":"Sanz-de la Garza","sequence":"additional","affiliation":[{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Cardiovascular Institute, Clinic Barcelona , Villarroel 170, 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-4372","authenticated-orcid":false,"given":"Gemma","family":"Sang\u00fcesa","sequence":"additional","affiliation":[{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Cardiovascular (CIBERCV) , Madrid ,","place":["Spain"]},{"name":"Department of Basic Sciences, Faculty of Health Sciences at Manresa, University of Vic - Central University of Catalonia (UVic-UCC) , Manresa, Catalonia ,","place":["Spain"]},{"name":"Tissue Repair and Regeneration Laboratory (TR2Lab), Institute for Research and Innovation in Life and Health Sciences in Central Catalonia (IRIS-CC) , Vic, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3515-620X","authenticated-orcid":false,"given":"Drilon","family":"Miftari","sequence":"additional","affiliation":[{"name":"Medicine and Translational Research Doctorate Programme, Faculty of Medicine, University of Barcelona , Casanova 143, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sitges","sequence":"additional","affiliation":[{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Cardiovascular Institute, Clinic Barcelona , Villarroel 170, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Cardiovascular (CIBERCV) , Madrid ,","place":["Spain"]},{"name":"Medicine Department, Faculty of Medicine, University of Barcelona . Casanova 143, 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Mont","sequence":"additional","affiliation":[{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Cardiovascular Institute, Clinic Barcelona , Villarroel 170, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Cardiovascular (CIBERCV) , Madrid ,","place":["Spain"]},{"name":"Medicine Department, Faculty of Medicine, University of Barcelona . Casanova 143, 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-2023","authenticated-orcid":false,"given":"Montserrat","family":"Batlle","sequence":"additional","affiliation":[{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Cardiovascular (CIBERCV) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-5319","authenticated-orcid":false,"given":"Eduard","family":"Guasch","sequence":"additional","affiliation":[{"name":"Institut D\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) , Rossell\u00f3 149, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Cardiovascular Institute, Clinic Barcelona , Villarroel 170, 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Cardiovascular (CIBERCV) , Madrid ,","place":["Spain"]},{"name":"Medicine Department, Faculty of Medicine, University of Barcelona . 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