{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:48Z","timestamp":1792785888587,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Longjiang Technology Talent Spring Goose Support Program","award":["CYQN24035"],"award-info":[{"award-number":["CYQN24035"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504500"],"award-info":[{"award-number":["82504500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200396"],"award-info":[{"award-number":["82200396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Heilongjiang Province of China","award":["PL2024H018"],"award-info":[{"award-number":["PL2024H018"]}]},{"name":"Undergraduate Universities of Heilongjiang Province","award":["YQJH2024238"],"award-info":[{"award-number":["YQJH2024238"]}]},{"name":"Innovation Team Project of Heilongjiang Provincial Department of Education","award":["2024-KYYWF-0620"],"award-info":[{"award-number":["2024-KYYWF-0620"]}],"id":[{"id":"https:\/\/ror.org\/059md9404","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Dongji Academic Team of Jiamusi University","award":["DJXSTD202412"],"award-info":[{"award-number":["DJXSTD202412"]}],"id":[{"id":"https:\/\/ror.org\/01vasff55","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated the association between metabolic obesity phenotypes and degenerative valvular heart disease (VHD) risk and elucidated the underlying molecular pathways via large-scale proteomics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We categorized 487 443 UK Biobank participants into four phenotypes based on body mass index and metabolic syndrome criteria: metabolically healthy normal weight (MHNO), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNO), and metabolically unhealthy obese (MUO). Multivariable-adjusted Cox models assessed the risk of VHD and its subtypes. We further integrated polygenic risk scores and plasma proteomic profiling to explore gene-environment interactions and biological mechanisms. Over a median 13.3-year follow-up, 12 793 participants (2.6%) developed degenerative VHD. Compared with MHNO, higher VHD risk was noted in MHO (HR 1.12, 95% CI 1.07\u20131.17) and MUO (HR 1.30, 95% CI 1.24\u20131.37) groups, but not MUNO (HR 1.05, 95% CI 0.92\u20131.19). Associations were most pronounced for aortic stenosis (AS) (MHO: HR 1.42, 95% CI 1.31\u20131.54; MUO: HR 1.67, 95% CI 1.32\u20132.11), modest for aortic regurgitation and insignificant for mitral regurgitation. Individuals with MUO and high genetic risk exhibited the highest AS risk (HR 2.91, 95% CI 2.51\u20133.36), although no significant interaction was found (P-interaction = 0.938). MUO exhibited the most distinct proteomic signatures, characterized by extensive overlap with AS-related proteins and enrichment in immune-inflammation, extracellular matrix remodelling, and MAPK signalling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Obesity is persistently associated with increased aortic valve pathology risk, indicating that MHO is not entirely benign. Concomitant metabolic dysfunction further compounds this risk, highlighting the need to integrate weight management with metabolic health optimization for VHD prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag492","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:10:48Z","timestamp":1789593048000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolic obesity phenotypes and degenerative valvular heart disease: a cohort study"],"prefix":"10.1093","author":[{"given":"Zhixin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Af\ufb01liated Hospital of Harbin Medical University , 246 Xuefu Road, Nangang District, Harbin 150086 ,","place":["China"]},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University , 258 Xuefu Road, Xiangyang District, Jiamusi 154007 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Bing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Af\ufb01liated Hospital of Harbin Medical University , 246 Xuefu Road, Nangang District, Harbin 150086 ,","place":["China"]},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University , 258 Xuefu Road, Xiangyang District, Jiamusi 154007 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University , 258 Xuefu Road, Xiangyang District, Jiamusi 154007 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University , 258 Xuefu Road, Xiangyang District, Jiamusi 154007 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Jiamusi University , Jiamusi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Jiamusi University , Jiamusi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Af\ufb01liated Hospital of Harbin Medical University , 246 Xuefu Road, Nangang District, Harbin 150086 ,","place":["China"]},{"name":"State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education , 246 Xuefu Road, Nangang District, Harbin 150086 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University , 258 Xuefu Road, Xiangyang District, Jiamusi 154007 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-1570","authenticated-orcid":false,"given":"Shanjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Af\ufb01liated Hospital of Harbin Medical University , 246 Xuefu Road, Nangang District, Harbin 150086 ,","place":["China"]},{"name":"State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education , 246 Xuefu Road, Nangang District, Harbin 150086 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