{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:45:45Z","timestamp":1791949545990,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["2023-12411-22209"],"award-info":[{"award-number":["2023-12411-22209"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Preeclampsia is associated with future cardiovascular disease (CVD), yet systematic approaches to identify those requiring intensified prevention are lacking. We aimed to characterize these women and identify subgroups at particularly high risk of later chronic hypertension or CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using Danish nationwide registries, we followed primiparous women with preeclampsia who gave birth during 2004\u201318 until December 2022. Using Poisson regression models, we estimated incidence rate ratios (IRRs) of later chronic hypertension or CVD. Of 17 434 women with preeclampsia, 2372 developed chronic hypertension and 373 developed CVD. Early-onset preeclampsia was more common among those who later developed chronic hypertension (13.3% vs. 7.4%) or CVD (12.1% vs. 8.1%). Higher incidence rates (IRs) of both outcomes [IRRs (95% confidence interval) for chronic hypertension and CVD, respectively] were found for smoking in pregnancy [1.20 (1.05\u20131.36); 1.24 (0.86\u20131.80)], gestational diabetes [1.36 (1.19\u20131.56); 1.25 (0.80\u20131.94)], pre-existing Type 1 diabetes [2.09 (1.57\u20132.78); 1.89 (0.77\u20134.59)] and type 2 diabetes [1.47 (0.93\u20132.33); 1.47 (0.36\u20136.01)], and low education [1.50 (1.31\u20131.72); 2.77 (1.92\u20133.98)]. The regions with the highest IRR differed between outcomes, and IRs were higher than among Danish-born women for some regions and lower for others. Incidence rates also increased with higher body mass index (BMI) and age, more steeply above 25\u2005kg\/m2 and 40 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early-onset preeclampsia, smoking, co-existing diabetes, certain ethnic origins, lower educational level, higher maternal age at delivery, and pre-pregnancy BMI \u2265 25\u2005kg\/m2 were identified as risk factors for later chronic hypertension or CVD among women with preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag507","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:01:24Z","timestamp":1790769684000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic hypertension and cardiovascular disease after preeclampsia: a Danish nationwide register-based cohort study identifying women at high risk"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8753-3816","authenticated-orcid":false,"given":"Helene","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Research, Steno Diabetes Center Greenland , Qatserisut 7A, Nuuk 3900 ,","place":["Greenland"]},{"name":"Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Copenhagen University Hospital , Borgmester Ib Juuls Vej 83, Herlev 2730 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5335-5505","authenticated-orcid":false,"given":"Gabriela Byskov","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Prevention, Health Promotion and Community Care, Copenhagen University Hospital \u2013 Steno Diabetes Center Copenhagen , Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-7938","authenticated-orcid":false,"given":"Maria Guldbrandt","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-2084","authenticated-orcid":false,"given":"Rasmus","family":"Wibaek","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Copenhagen University Hospital , Borgmester Ib Juuls Vej 83, Herlev 2730 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-5098","authenticated-orcid":false,"given":"Jesper James","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-5246","authenticated-orcid":false,"given":"Peter","family":"Damm","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-3609","authenticated-orcid":false,"given":"Stine","family":"Byberg","sequence":"additional","affiliation":[{"name":"Department of Research, Steno Diabetes Center Greenland , Qatserisut 7A, Nuuk 3900 ,","place":["Greenland"]},{"name":"Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Copenhagen University Hospital , Borgmester Ib Juuls Vej 83, Herlev 2730 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-0615","authenticated-orcid":false,"given":"Karoline","family":"Kragelund Nielsen","sequence":"additional","affiliation":[{"name":"Department of Prevention, Health Promotion and Community Care, Copenhagen University Hospital \u2013 Steno Diabetes Center Copenhagen , Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101323012563800_zwag507-B1","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The Lancet Women and Cardiovascular Disease Commission: reducing the global burden by 2030","volume":"397","author":"Vogel","year":"2021","journal-title":"The Lancet"},{"key":"2026101323012563800_zwag507-B2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"The Lancet"},{"key":"2026101323012563800_zwag507-B3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11906-013-0329-4","article-title":"Preeclampsia and the future risk of hypertension: the pregnant evidence","volume":"15","author":"Garovic","year":"2013","journal-title":"Curr Hypertens Rep"},{"key":"2026101323012563800_zwag507-B4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.116.003497","article-title":"Preeclampsia and future cardiovascular health: a systematic review and meta-analysis","volume":"10","author":"Wu","year":"2017","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2026101323012563800_zwag507-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10654-013-9762-6","article-title":"Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis","volume":"28","author":"Brown","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"2026101323012563800_zwag507-B6","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2026101323012563800_zwag507-B7"},{"key":"2026101323012563800_zwag507-B8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/1471-0528.16545","article-title":"Incidence of postpartum hypertension within 2 years of a pregnancy complicated by pre-eclampsia: a systematic review and meta-analysis","volume":"128","author":"Giorgione","year":"2021","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"2026101323012563800_zwag507-B9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish civil registration system","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"key":"2026101323012563800_zwag507-B10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10654-018-0356-1","article-title":"The Danish medical birth register","volume":"33","author":"Bliddal","year":"2018","journal-title":"Eur J 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Core Team"},{"key":"2026101323012563800_zwag507-B17","doi-asserted-by":"crossref","first-page":"101371","DOI":"10.1016\/j.ajogmf.2024.101371","article-title":"Early-onset vs late-onset preeclampsia and risk of coronary atherosclerosis later in life: a clinical follow-up study","volume":"6","author":"Hauge","year":"2024","journal-title":"Am J Obstet Gynecol MFM"},{"key":"2026101323012563800_zwag507-B18","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/bmj.39335.385301.BE","article-title":"Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis","volume":"335","author":"Bellamy","year":"2007","journal-title":"BMJ"},{"key":"2026101323012563800_zwag507-B19","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/HYPERTENSIONAHA.114.04850","article-title":"Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced 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disparities in cardiovascular complications with pregnancy-induced hypertension in the United States","volume":"78","author":"Minhas","year":"2021","journal-title":"Hypertension"},{"key":"2026101323012563800_zwag507-B32","doi-asserted-by":"crossref","first-page":"1701507","DOI":"10.3389\/fcvm.2026.1701507","article-title":"Subtypes and onset of hypertensive disorders of pregnancy and cardiovascular disease within 5 years after delivery","volume":"13","author":"Hu","year":"2026","journal-title":"Front Cardiovasc Med"},{"key":"2026101323012563800_zwag507-B33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1403494810394715","article-title":"Danish education registers","volume":"39","author":"Jensen","year":"2011","journal-title":"Scand J Public Health"},{"key":"2026101323012563800_zwag507-B34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/CLEP.S441123","article-title":"Validation of obstetric diagnosis and procedure codes in the Danish national patient 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