{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:50:37Z","timestamp":1791546637854,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Higher physical activity (PA) has been associated with lower all-cause mortality in patients with coronary heart disease (CHD), but the dose\u2013response relationship remains uncertain. We conducted a systematic review and dose\u2013response meta-analysis to quantify the association between non-occupational PA and all-cause mortality in CHD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We systematically searched six databases in November 2025 for prospective cohort studies reporting non-occupational PA and all-cause mortality in CHD patients. Physical activity data were harmonized to marginal metabolic equivalent of task hours\/week (mMET-h\/week). We performed two-stage random-effects dose\u2013response meta-analysis using restricted cubic splines. Risk of bias was assessed using the JBI checklist. Seventeen studies included 176 862 patients; 16 reported 31 783 study-level deaths. The primary dose\u2013response curve was modelled over 0\u201340 mMET-h\/week and showed a non-linear inverse association (P for non-linearity &amp;lt;0.001; I2 = 84.7%). Relative to 0 mMET-h\/week, estimated mortality risk was 38% lower at 8.75 mMET-h\/week (RR = 0.62, 95% CI: 0.54\u20130.73) and 39% lower at 17.5 mMET-h\/week (RR = 0.61, 95% CI: 0.47\u20130.79). At 30 mMET-h\/week, the estimate was imprecise (RR = 0.92, 95% CI: 0.51\u20131.67), only 8 of 17 studies had data extending to this knot, and alternative harmonization assumptions produced a different high-dose shape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher non-occupational PA was associated with lower all-cause mortality in CHD, particularly at low-to-moderate levels. These activity levels were consistent with the range recommended in current ESC guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag510","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:45:14Z","timestamp":1790682314000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-occupational physical activity and all-cause mortality in patients with coronary heart disease: a dose\u2013response meta-analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7858-3827","authenticated-orcid":false,"given":"Zhiwei","family":"Tao","sequence":"first","affiliation":[{"name":"Physical Activity for Health Research Centre, University of Edinburgh , Edinburgh EH8 8AQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxu","family":"Hu","sequence":"additional","affiliation":[{"name":"Physical Activity for Health Research Centre, University of Edinburgh , Edinburgh EH8 8AQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Physical Activity for Health Research Centre, University of Edinburgh , Edinburgh EH8 8AQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-1047","authenticated-orcid":false,"given":"Tessa","family":"Strain","sequence":"additional","affiliation":[{"name":"Physical Activity for Health Research Centre, University of Edinburgh , Edinburgh EH8 8AQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"2026100906563458500_zwag510-B1","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes: developed by the task force for the management of chronic coronary 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