{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:32:09Z","timestamp":1793381529494,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF21OC0068242"],"award-info":[{"award-number":["NNF21OC0068242"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004798","name":"TBS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004331","name":"Snedkermester Sophus Jacobsen og hustru Astrid Jacobsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R323-2018-3674"],"award-info":[{"award-number":["R323-2018-3674"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This trial investigated whether colchicine, an anti-inflammatory treatment, affects cardiovascular structure and function, assessed by arterial stiffness, blood pressure, and biochemistry, compared with placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>COHERENT was a randomized, double-blind, placebo-controlled trial of the effects of colchicine on arterial stiffness in adults with pharmacologically treated hypertension without cardiovascular disease. Eligible patients were randomized 1:1 to colchicine 0.5\u2005mg daily or placebo for 6 months. Assessment of arterial stiffness, echocardiography, and biomarker measurement were performed at baseline and 6 months. The primary endpoint was change in carotid-femoral pulse wave velocity (cfPWV). Secondary endpoints included change in blood pressure (BP), left ventricular mass index, as well as change in cardiac and inflammatory biomarkers. Of 183 screened, 150 were randomized (75 per group). The mean age was 64.5 (\u00b18.0) years, 53 (35.3%) were female, and mean systolic blood pressure was 140.3 (\u00b116.5) mmHg. At 6 months, cfPWV did not differ between groups [between-group difference in \u0394cfPWV \u22120.1\u2005m\/s, 95% confidence interval (CI): \u22120.5 to 0.3\u2005m\/s, P = 0.53]. Office systolic BP decreased significantly more in the placebo group than in the colchicine group (between-group difference in \u0394office systolic BP 5.7\u2005mmHg, 95% CI: 1.0 to 10.5\u2005mmHg, P = 0.018). hsCRP decreased significantly in the colchicine group compared with the placebo group (between-group difference in % change in hsCRP \u221239.8%, 95% CI: \u221259.1 to \u221211.4%, P = 0.010). The left ventricular mass index or cardiac biomarkers did not differ between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Six months of colchicine did not affect arterial stiffness in pharmacologically treated hypertension without cardiovascular disease. Colchicine significantly decreased hsCRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov: https:\/\/clinicaltrials.gov\/study\/NCT04916522<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwag527","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:47:45Z","timestamp":1792064865000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of colchicine on arterial stiffness in patients with hypertension: the COlchicine HypERtENsion Trial (COHERENT)"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-2938","authenticated-orcid":false,"given":"Adam Femerling","family":"Langhoff","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Center for 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Vu","family":"Bartholdy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Gentofte Hospitalsvej 8, Hellerup 2900, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-7460","authenticated-orcid":false,"given":"Julie Inge-Marie Helene","family":"Borchsenius","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Gentofte Hospitalsvej 8, Hellerup 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